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[...]they attach to the penicillin binding proteins that normally suppress cell wall hydrolases, thus freeing these hydrolases, which in turn act to lyse the bacterial cell wall. Generally, an isolate is suspected to be an ESBL producer when it shows in vitro susceptibility to the second generation...

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Bibliographic Details
Published in:BMJ 2003-11, Vol.327 (7425), p.1209-1213
Main Author: Samaha-Kfoury, J. N
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial agents
Bacteria
Bacterial infections
Cell division
Deoxyribonucleic acid
DNA
E coli
Enzymes
Infections
Medical laboratories
Patients
Protein synthesis
Proteins
RNA polymerase
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Summary:[...]they attach to the penicillin binding proteins that normally suppress cell wall hydrolases, thus freeing these hydrolases, which in turn act to lyse the bacterial cell wall. Generally, an isolate is suspected to be an ESBL producer when it shows in vitro susceptibility to the second generation cephalosporins (cefoxitin, cefotetan) but resistance to the third generation cephalosporins and to aztreonam. [...]one should suspect these strains when treatment with these agents for Gram negative infections fails despite reported in vitro susceptibility.
ISSN:0959-8138
1468-5833
DOI:10.1136/bmj.327.7425.1209