Red and processed meat consumption and mortality: dose–response meta-analysis of prospective cohort studies

To examine and quantify the potential dose-response relationship between red and processed meat consumption and risk of all-cause, cardiovascular and cancer mortality. We searched MEDLINE, Embase, ISI Web of Knowledge, CINHAL, Scopus, the Cochrane library and reference lists of retrieved articles up...

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Bibliographic Details
Published in:	Public health nutrition 2016-04, Vol.19 (5), p.893-905
Main Authors:	Wang, Xia, Lin, Xinying, Ouyang, Ying Y, Liu, Jun, Zhao, Gang, Pan, An, Hu, Frank B
Format:	Article
Language:	eng
Subjects:	Cardiovascular Diseases - mortality Databases, Factual Humans Linear Models Meat Products - adverse effects Neoplasms - mortality Nutritional epidemiology Red Meat - adverse effects Reproducibility of Results Review Article Risk Factors Sensitivity and Specificity
Online Access:	Get full text
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Summary:	To examine and quantify the potential dose-response relationship between red and processed meat consumption and risk of all-cause, cardiovascular and cancer mortality. We searched MEDLINE, Embase, ISI Web of Knowledge, CINHAL, Scopus, the Cochrane library and reference lists of retrieved articles up to 30 November 2014 without language restrictions. We retrieved prospective cohort studies that reported risk estimates for all-cause, cardiovascular and cancer mortality by red and/or processed meat intake levels. The dose-response relationships were estimated using data from red and processed meat intake categories in each study. Random-effects models were used to calculate pooled relative risks and 95 % confidence intervals and to incorporate between-study variations. Nine articles with seventeen prospective cohorts were eligible in this meta-analysis, including a total of 150 328 deaths. There was evidence of a non-linear association between processed meat consumption and risk of all-cause and cardiovascular mortality, but not for cancer mortality. For processed meat, the pooled relative risk with an increase of one serving per day was 1·15 (95 % CI 1·11, 1·19) for all-cause mortality (five studies; P
ISSN:	1368-9800 1475-2727