Bovine Papillomavirus: New Insights into an Old Disease

Bovine papillomaviruses (BPVs) are small DNA tumoral viruses able to induce benign cutaneous and/or mucosal epithelial lesions. Generally, the benign tumours affecting the skin or mucosa spontaneously regress, but under special circumstances, the defence system may be overwhelmed, thus leading to ca...

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Bibliographic Details
Published in:Transboundary and emerging diseases 2016-02, Vol.63 (1), p.14-23
Main Authors: Bocaneti, F., Altamura, G., Corteggio, A., Velescu, E., Roperto, F., Borzacchiello, G.
Format: Article
Language:English
Subjects:
Animals
bovine papillomavirus
Bovine papillomavirus 1 - classification
Bovine papillomavirus 1 - genetics
Cattle
Cattle Diseases - epidemiology
Cattle Diseases - virology
Epidemiology
Genotype
Neoplasms - veterinary
Neoplasms - virology
Papillomavirus Infections - epidemiology
Papillomavirus Infections - veterinary
Papillomavirus Infections - virology
Tumors
viral oncology
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Summary:Bovine papillomaviruses (BPVs) are small DNA tumoral viruses able to induce benign cutaneous and/or mucosal epithelial lesions. Generally, the benign tumours affecting the skin or mucosa spontaneously regress, but under special circumstances, the defence system may be overwhelmed, thus leading to cancer, especially in the presence of immunosuppressant and mutagen agents from bracken fern. To date, thirteen different BPV genotypes have been associated with skin and mucosal tumours in cattle, and out of these, only four types (BPV‐1, ‐2, ‐5 and ‐13) cross‐infect other species. Recent investigations in vivo have revealed new insights into the epidemiology and pathogenesis of this viral infection. This review briefly discusses viral epidemiology, will give data on BPV genome structure and viral genes and will describe the cellular events and new aspects of both cutaneous and mucosal tumours in large ruminants. Finally, some aspects of active immunization will be described.
ISSN:1865-1674
1865-1682
DOI:10.1111/tbed.12222