Smart nanosystems: Bio-inspired technologies that interact with the host environment

Nanoparticle technologies intended for human administration must be designed to interact with, and ideally leverage, a living host environment. Here, we describe smart nanosystems classified in two categories: (i) those that sense the host environment and respond and (ii) those that first prime the...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2015-11, Vol.112 (47), p.14460-14466
Main Authors: Kwon, Ester J., Lo, Justin H., Bhatia, Sangeeta N.
Format: Article
Language:English
Subjects:
Biological Sciences
Diagnostics
Homeostasis
Humans
Hydrogen-Ion Concentration
Nanomedicine
Nanoparticles
Nanotechnology
Oxidation-Reduction
Physical Sciences
SPECIAL FEATURE: PERSPECTIVE
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Summary:Nanoparticle technologies intended for human administration must be designed to interact with, and ideally leverage, a living host environment. Here, we describe smart nanosystems classified in two categories: (i) those that sense the host environment and respond and (ii) those that first prime the host environment to interact with engineered nanoparticles. Smart nanosystems have the potential to produce personalized diagnostic and therapeutic schema by using the local environment to drive material behavior and ultimately improve human health.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1508522112