Stereoselective Total Synthesis of Mangiferaelactone using D-Mannose as a Chiral Pool

A convergent total synthesis of mangiferaelactone has been accomplished in a highly stereoselective manner from readily available D‐mannose. The following methods like organocatalytic enantioselective epoxidation, ring‐closing metathesis, and Steglich esterification have been employed as key steps,...

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Bibliographic Details
Published in:Helvetica chimica acta 2015-10, Vol.98 (10), p.1395-1402
Main Authors: Reddy, Basi V. Subba, Reddy, Pathuri Sivaramakrishna, Babu, Kummari Vijaya, Reddy, Bhemavarapu Phaneendra, Yadav, Jhillu Singh
Format: Article
Language:English
Subjects:
10-Membered macrolides
MacMillan asymmetric epoxidation
Ring-closing metathesis
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Summary:A convergent total synthesis of mangiferaelactone has been accomplished in a highly stereoselective manner from readily available D‐mannose. The following methods like organocatalytic enantioselective epoxidation, ring‐closing metathesis, and Steglich esterification have been employed as key steps, which make this approach more attractive.
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201500103