Inhibition of viral protein translation by indomethacin in vesicular stomatitis virus infection: role of eIF2[alpha] kinase PKR

Summary Indomethacin, a cyclooxygenase-1 and -2 inhibitor widely used in the clinic for its potent anti-inflammatory/analgesic properties, possesses antiviral activity against several viral pathogens; however, the mechanism of antiviral action remains elusive. We have recently shown that indomethaci...

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Bibliographic Details
Published in:Cellular microbiology 2015-09, Vol.17 (9), p.1391
Main Authors: Amici, Carla, La Frazia, Simone, Brunelli, Claudia, Balsamo, Mirna, Angelini, Mara, Santoro, M Gabriella
Format: Article
Language:English
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Summary:Summary Indomethacin, a cyclooxygenase-1 and -2 inhibitor widely used in the clinic for its potent anti-inflammatory/analgesic properties, possesses antiviral activity against several viral pathogens; however, the mechanism of antiviral action remains elusive. We have recently shown that indomethacin activates the double-stranded RNA (dsRNA)-dependent protein kinase R (PKR) in human colon cancer cells. Because of the important role of PKR in the cellular defence response against viral infection, herein we investigated the effect of indomethacin on PKR activity during infection with the prototype rhabdovirus vesicular stomatitis virus. Indomethacin was found to activate PKR in an interferon- and dsRNA-independent manner, causing rapid (
ISSN:1462-5814
1462-5822
DOI:10.1111/cmi.12446