Incidence and natural history of challenge‐proven cow's milk allergy in European children – EuroPrevall birth cohort

Background Cow's milk allergy (CMA) is one of the most commonly reported childhood food problems. Community‐based incidence and prevalence estimates vary widely, due to possible misinterpretations of presumed reactions to milk and differences in study design, particularly diagnostic criteria. M...

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Bibliographic Details
Published in:Allergy (Copenhagen) 2015-08, Vol.70 (8), p.963-972
Main Authors: Schoemaker, A. A., Sprikkelman, A. B., Grimshaw, K. E., Roberts, G., Grabenhenrich, L., Rosenfeld, L., Siegert, S., Dubakiene, R., Rudzeviciene, O., Reche, M., Fiandor, A., Papadopoulos, N. G., Malamitsi‐Puchner, A., Fiocchi, A., Dahdah, L., Sigurdardottir, S. Th, Clausen, M., Stańczyk‐Przyłuska, A., Zeman, K., Mills, E. N. C., McBride, D., Keil, T., Beyer, K.
Format: Article
Language:English
Subjects:
Age Distribution
Allergens - immunology
Animals
birth cohort study
Cattle
Child
Child, Preschool
Children & youth
Cohort Studies
cow's milk allergy
Double-Blind Method
Europe - epidemiology
EuroPrevall
Female
Food allergies
food allergy
Humans
Immunoglobulin E - immunology
Incidence
Infant
Male
Milk
Milk Hypersensitivity - diagnosis
Milk Hypersensitivity - epidemiology
Milk Proteins - adverse effects
Milk Proteins - immunology
Severity of Illness Index
Sex Distribution
Skin Tests - methods
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Summary:Background Cow's milk allergy (CMA) is one of the most commonly reported childhood food problems. Community‐based incidence and prevalence estimates vary widely, due to possible misinterpretations of presumed reactions to milk and differences in study design, particularly diagnostic criteria. Methods Children from the EuroPrevall birth cohort in 9 European countries with symptoms possibly related to CMA were invited for clinical evaluation including cows' milk‐specific IgE antibodies (IgE), skin prick test (SPT) reactivity and double‐blind, placebo‐controlled food challenge. Results Across Europe, 12 049 children were enrolled, and 9336 (77.5%) were followed up to 2 years of age. CMA was suspected in 358 children and confirmed in 55 resulting in an overall incidence of challenge‐proven CMA of 0.54% (95% CI 0.41–0.70). National incidences ranged from 1% (in the Netherlands and UK) to
ISSN:0105-4538
1398-9995
DOI:10.1111/all.12630