Translational regulation of exocrine cell function and survival by ATF4-dependent expression of 4E-BP1

In turn, 4E-BP1 provides a critical regulatory point by controlling on demand the massive synthesis of secreted proteins. 4E-BP1 also creates a protective feedback loop that limits the translation of CHOP mRNA, a transcription factor which otherwise induces cell death.

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Bibliographic Details
Published in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2015-06, Vol.15 (3), p.S48-S48
Main Authors: Pyronnet, Stéphane, Lasfargues, Charline, Martineau, Yvan, Müller, David, Hess, David A, DiRenzo, Daniel, Khoutorsky, Arkady, Baer, Romain, Guillermet-Guibert, Julie, Sonenberg, Nahum, Konieczny, Stephen F, Bousquet, Corinne
Format: Article
Language:English
Subjects:
Endocrinology & Metabolism
Gastroenterology and Hepatology
Genes
Pancreas
Protein synthesis
Proteins
Rodents
Transcription factors
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Description
Summary:In turn, 4E-BP1 provides a critical regulatory point by controlling on demand the massive synthesis of secreted proteins. 4E-BP1 also creates a protective feedback loop that limits the translation of CHOP mRNA, a transcription factor which otherwise induces cell death.
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2015.05.196