Olanzapine-Induced Malignant Neuroleptic Syndrome

Neuroleptic Malign Sydrome (NMS), caused by antipsychotic therapy, which shows itself with mental status alteration, high fever, autonomic dysfunction and muscle rigidity. It is a rare idiosyncratic reaction with mortality risk. Aetiology is still unknown. NMS related mortality and morbidity can be...

Full description

Saved in:
Bibliographic Details
Published in:Turkish journal of anaesthesiology and reanimation 2014-10, Vol.42 (5), p.288
Main Authors: Tuba Berra Saritas, Çankaya, Baris, Alper Yosunkaya
Format: Article
Language:English
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neuroleptic Malign Sydrome (NMS), caused by antipsychotic therapy, which shows itself with mental status alteration, high fever, autonomic dysfunction and muscle rigidity. It is a rare idiosyncratic reaction with mortality risk. Aetiology is still unknown. NMS related mortality and morbidity can be decreased by cessation of the used drug and aggressive treatment. Olanzapine is a thienobenzodiazepine group atypical antipsychotic drug, its structure and effects on neurotransmitter resembles clozapine. We aimed to report a NMS case that was without rigidity and with bipolar disorder receiving olanzapine therapy for 10 years. We emphasized the importance of early hydration and haemodiafiltration therapy.
ISSN:2667-677X
2667-6370
DOI:10.5152/TJAR.2014.46704