The Correlation Between Plasma Tissue Factor and Interleukin 18 and Their Significance in Patients with Acute Coronary Syndrome

Studies suggested that the activation of the coagulation system and inflammation mutually may reinforce each other in some cases. In this study, we test the plasma tissue factor (TF) and interleukin 18 in patients with coronary heart disease (CHD) before and after treatment and aim to determine whet...

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Bibliographic Details
Published in:Cardiovascular toxicology 2015-07, Vol.15 (3), p.276-282
Main Authors: Li, Qiaowen, Kuang, Yulan, Qiu, Jian, Zhang, Xiaoyong, Ruan, Yunjun, Li, Zhiliang
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - blood
Acute Coronary Syndrome - diagnosis
Acute Coronary Syndrome - therapy
Acute coronary syndromes
Aged
Angina pectoris
Biomarkers - blood
Biomedical and Life Sciences
Biomedicine
Cardiac patients
Cardiology
Cardiovascular disease
Care and treatment
Clopidogrel
Coronary vessels
Cytokines
Development and progression
Enzyme-linked immunosorbent assay
Enzymes
Female
Follow-Up Studies
Hospitals
Humans
Inflammation
Interleukin-18 - blood
Interleukins
Male
Medical imaging
Middle Aged
Percutaneous Coronary Intervention - trends
Pharmacology/Toxicology
Plasma
Thromboplastin - metabolism
Thrombosis
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Summary:Studies suggested that the activation of the coagulation system and inflammation mutually may reinforce each other in some cases. In this study, we test the plasma tissue factor (TF) and interleukin 18 in patients with coronary heart disease (CHD) before and after treatment and aim to determine whether this relationship exists in patients with CHD. The levels of plasma TF and IL-18 from 118 patients with CHD were determined by enzyme-linked immunosorbent assay. One hundred and eighteen patients were divided into acute coronary syndrome (ACS) group (61 cases) and stable angina pectoris group (51 cases). Upon admission, patients with ACS showed significantly higher levels of plasma TF and interleukin 18 compared with those having stable angina ( P   0.05). The results suggest that levels of plasma TF and interleukin 18 are significantly increased in patients with ACS, and there is significant correlation between the two, indicating an interaction between inflammation and coagulation in patients with ACS and an important role of these two in the occurrence and development of such disease.
ISSN:1530-7905
1559-0259
DOI:10.1007/s12012-014-9296-5