TACC3 promotes epithelial–mesenchymal transition (EMT) through the activation of PI3K/Akt and ERK signaling pathways

Highlights ► TACC3 has an ability to regulate cell proliferation, migration, invasion and transformation. ► Overexpression of TACC3 promotes EMT, at least in part, through the up-regulation of PI3K/Akt and ERK signaling pathways. ► Depletion of TACC3 reverses EMT.

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Bibliographic Details
Published in:Cancer letters 2013-05, Vol.332 (1), p.63-73
Main Authors: Ha, Geun-Hyoung, Park, Jong-Sup, Breuer, Eun-Kyoung Yim
Format: Article
Language:English
Subjects:
Acquisitions & mergers
Akt
beta Catenin - metabolism
carcinogenesis
Cell Movement
Cell Proliferation
Cell Shape
Cell Transformation, Neoplastic - metabolism
Cell Transformation, Neoplastic - pathology
Cervical cancer
Chromosomes
EMT
Enzyme Activation
Epidermal growth factor
Epithelial-Mesenchymal Transition - drug effects
ERKs
Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors
Extracellular Signal-Regulated MAP Kinases - genetics
Extracellular Signal-Regulated MAP Kinases - metabolism
Fluorides
Gene expression
HEK293 Cells
HeLa Cells
Hematology, Oncology and Palliative Medicine
Humans
Kinases
Metastasis
Microtubule-Associated Proteins - genetics
Microtubule-Associated Proteins - metabolism
migratory behavior
mitosis
mitotic spindle apparatus
Mutation
Neoplasm Invasiveness
Ovarian cancer
phenotype
phosphatidylinositol 3-kinase
Phosphatidylinositol 3-Kinase - antagonists & inhibitors
Phosphatidylinositol 3-Kinase - metabolism
Phosphorylation
PI3K
Plasmids
Protein Kinase Inhibitors - pharmacology
protein kinases
Proteins
Proto-Oncogene Proteins c-akt - antagonists & inhibitors
Proto-Oncogene Proteins c-akt - genetics
Proto-Oncogene Proteins c-akt - metabolism
RNA Interference
signal transduction
Signal Transduction - drug effects
Sodium
Studies
TACC3
Time Factors
Transfection
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Description
Summary:Highlights ► TACC3 has an ability to regulate cell proliferation, migration, invasion and transformation. ► Overexpression of TACC3 promotes EMT, at least in part, through the up-regulation of PI3K/Akt and ERK signaling pathways. ► Depletion of TACC3 reverses EMT.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.01.013