Prognostic impact of ^sup 18^F-FDG PET/CT staging and of pathological response to neoadjuvant chemotherapy in triple-negative breast cancer

Mortality is high in patients with locally advanced triple-negative breast cancer (TNBC), especially in those with residual tumour after neoadjuvant chemotherapy (NAC). The aim of this study was to determine if pretreatment ^sup 18^F-FDG PET/CT staging and pathological findings after NAC could toget...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2015-03, Vol.42 (3), p.377
Main Authors: Groheux, D, Giacchetti, S, Delord, M, de Roquancourt, A, Merlet, P, Hamy, A S, Espié, M, Hindié, E
Format: Article
Language:English
Subjects:
Breast cancer
Chemotherapy
Medical prognosis
Tomography
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Summary:Mortality is high in patients with locally advanced triple-negative breast cancer (TNBC), especially in those with residual tumour after neoadjuvant chemotherapy (NAC). The aim of this study was to determine if pretreatment ^sup 18^F-FDG PET/CT staging and pathological findings after NAC could together allow stratification of patients into prognostic groups. Initial staging with ^sup 18^F-FDG PET/CT was performed prospectively in 85 consecutive patients with stage II/III TNBC. Correlations between PET findings and disease-specific survival (DSS) were examined. In patients without distant metastases on PET staging, the impact of pathological response to NAC on DSS was examined. Patterns of recurrence were also analysed. ^sup 18^F-DG PET/CT revealed distant metastases in 11 of 85 patients (12.9 %). Among 74 M0 patients, 23 (31.1 %) showed a pathological complete response (pCR) at surgery, while 51 had residual invasive disease (no pCR). DSS differed considerably among the three groups of patients (log-rank P
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-014-2941-1