The relationship between coronary collateral artery development and inflammatory markers

This study aims to show the effect of myeloperoxidase (MPO), hsCRP, TNF-alpha values and leukocyte count on the development of coronary collateral arteries in patients with severely diseased coronary arteries. Current study is an observational cross-sectional study. In the study, 295 patients who ha...

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Bibliographic Details
Published in:Anadolu kardiyoloji dergisi : AKD 2014-06, Vol.14 (4), p.336-341
Main Authors: Oğuz, Didem, Atmaca, Yusuf, Ozdöl, Cağdaş, Ozdemir, Ayhan Ongun, Kaya, Cansin Tulunay, Erol, Cetin
Format: Article
Language:English
Subjects:
Biomarkers - blood
Collateral Circulation
Coronary Artery Disease - blood
Coronary Artery Disease - pathology
Coronary Artery Disease - physiopathology
Cross-Sectional Studies
Female
Humans
Logistic Models
Male
Middle Aged
Peroxidase - blood
Predictive Value of Tests
Severity of Illness Index
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Summary:This study aims to show the effect of myeloperoxidase (MPO), hsCRP, TNF-alpha values and leukocyte count on the development of coronary collateral arteries in patients with severely diseased coronary arteries. Current study is an observational cross-sectional study. In the study, 295 patients who had functional obstruction or total coronary occlusion at least 1 month on their angiograms were included. We divided the study population into two groups according to their collateral grade as good collateral (Group 1) (169 patients) and poor collateral (Group 2) (126 patients). Multiple logistic regression analysis was used for independent variables associated with the coronary collateral grade. History of stable angina pectoris was statistically more prevalent in good collateral group (61.5% and 48.4%, p=0.025). Furthermore, MPO activation was higher in good collateral group and the difference was statistically significant (3.7 U/mL and 3.0 U/mL p=0.001). In multiple logistic regression analysis, stable angina pectoris [OR 1.7, 95% CI (1.05-2.8), p=0.03] and high MPO levels [OR 2.7, 95% CI (1.7-4.3), p
ISSN:1302-8723
2149-2263
1308-0032
2149-2271
DOI:10.5152/akd.2014.4612