Loss of epithelial p53 and [alpha]v integrin cooperate through Akt to induce squamous cell carcinoma yet prevent remodeling of the tumor microenvironment

Most of the squamous cell carcinomas (SCCs) of the skin and head and neck contain p53 mutations. The presence of p53 mutations in premalignant lesions suggests that they represent early events during tumor progression and additional alterations may be required for SCC development. Here we show that...

Full description

Saved in:
Bibliographic Details
Published in:Oncogene 2015-01, Vol.34 (4), p.516
Main Authors: Savar, A, Acin, S, Gonzalez, C L, El-sawy, T, Mejia, O, Li, Z, Esmaeli, B, Lacy-hulbert, A, El-naggar, A K, Mccarty, J H, Caulin, C
Format: Article
Language:English
Subjects:
Cancer
Cells
Head & neck cancer
Mutation
Tumors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Most of the squamous cell carcinomas (SCCs) of the skin and head and neck contain p53 mutations. The presence of p53 mutations in premalignant lesions suggests that they represent early events during tumor progression and additional alterations may be required for SCC development. Here we show that codeletion of the p53 and av integrin genes in mouse stratied epithelia induced SCCs in 100% of the mice, more frequently and with much shorter latency than deletion of either gene alone. The SCCs that lacked p53 and av in the epithelial tumor cells exhibited high Akt activity, lacked multiple types of inltrating immune cells, contained a defective vasculature and grew slower than tumors that expressed p53 or av. These results reveal that loss of av in epithelial cells that lack p53 promotes SCC development, but also prevents remodeling of the tumor microenvironment and delays tumor growth.
ISSN:0950-9232
1476-5594
DOI:10.1038/onc.2013.585