Efficient and Green Microwave-Assisted Multicomponent Biginelli Reaction for the Synthesis of Dihydropyrimidinones Catalyzed by Heteropolyanion-Based Ionic Liquids Under Solvent-Free Conditions

An efficient and green route for the synthesis of dihydropyrimidinones via microwave-assisted Biginelli reaction catalyzed by 3 mol% of heteropolyanion-based ionic liquids under solvent-free conditions has been reported. The practical reaction was found to be compatible with different structurally d...

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Bibliographic Details
Published in:Synthetic communications 2015-02, Vol.45 (4), p.467-477
Main Authors: Fu, Renzhong, Yang, Yang, Lai, Wenchen, Ma, Yongfeng, Chen, Zhikai, Zhou, Jian, Chai, Wen, Wang, Quan, Yuan, Rongxin
Format: Article
Language:English
Subjects:
Biginelli reaction
dihydropyrimidinone
ionic liquid
microwave
solvent-free condition
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Summary:An efficient and green route for the synthesis of dihydropyrimidinones via microwave-assisted Biginelli reaction catalyzed by 3 mol% of heteropolyanion-based ionic liquids under solvent-free conditions has been reported. The practical reaction was found to be compatible with different structurally diverse substrates. Good to excellent yields, short reaction times, and operational simplicity are the main highlights of this protocol. Moreover, the heteropolyanion-based ionic liquids were easily reusable for this Biginelli reaction.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2014.976346