The overlapping and the correlation between D-dimer and C-reactive protein in patients with community-acquired pneumonia and pulmonary embolism

Coagulation abnormalities are present in pulmonary embolism (PE), but they are frequent in patients with severe infections, too. Elevated proinflammatory cytokines in patients with community-acquired pneumonia (CAP) lead to elevated D-dimer. We have analyzed plasma D-dimer and serum CRP in 37 patien...

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Bibliographic Details
Published in:International public health journal 2014-01, Vol.6 (1), p.41
Main Authors: Nastasijevic-Borovac, Desa, Petkovic, Tatjana Radjenovic, Pejcic, Tatjana, Stankovic, Ivana
Format: Article
Language:English
Subjects:
Age
Disease
Drug therapy
Embolisms
Hemophilia
Laboratories
Medical prognosis
Mortality
Pneumonia
Pregnancy
Proteins
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Summary:Coagulation abnormalities are present in pulmonary embolism (PE), but they are frequent in patients with severe infections, too. Elevated proinflammatory cytokines in patients with community-acquired pneumonia (CAP) lead to elevated D-dimer. We have analyzed plasma D-dimer and serum CRP in 37 patients with PE and 108 patients with CAP. The Pneumonia Severity Index was used to classify CAP patients into groups: Group I, Group II and Group III. Group IV, consisted of patients with PE. There was no CRP difference among the Group I and Group IV. Plasma D-dimer correlates with the severity of CAP. There were no differences in plasma D-dimer in the severe CAP and PE. The correlation between serum CRP and plasma D-dimer persist in non-severe CAP. D-dimer was higher in Group IV than in survivor CAP patients, but not higher than in non-survivor CAP patients. Positive correlation between CRP and D-dimer persists in non-severe CAP. In severe CAP, increases of Ddimer are influenced by inflammatory markers, accompanying diseases, patient's age and the severity of disease.
ISSN:1947-4989
2374-1023