Cystic fibrosis transmembrane conductance regulator is correlated closely with sperm progressive motility and normal morphology in healthy and fertile men with normal sperm parameters

Summary Cystic fibrosis transmembrane conductance regulator (CFTR) has been demonstrated to be expressed in mature spermatozoa and correlated with sperm quality. Sperm CFTR expression in fertile men is higher than that in infertile men suffering from teratospermia, asthenoteratospermia, asthenosperm...

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Published in:Andrologia 2014-10, Vol.46 (8), p.824-830
Main Authors: Jiang, L.-Y., Shan, J.-J., Tong, X.-M., Zhu, H.-Y., Yang, L.-Y., Zheng, Q., Luo, Y., Shi, Q.-X., Zhang, S.-Y.
Format: Article
Language:English
Subjects:
Adult
Age
Aging - metabolism
Biomarkers - metabolism
cystic fibrosis transmembrane conductance regulator
Cystic Fibrosis Transmembrane Conductance Regulator - metabolism
Fertility
Healthy Volunteers
human spermatozoa
Humans
Male
Middle Aged
morphology
motility
Sperm Motility
Spermatozoa - cytology
Spermatozoa - metabolism
Young Adult
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Summary:Summary Cystic fibrosis transmembrane conductance regulator (CFTR) has been demonstrated to be expressed in mature spermatozoa and correlated with sperm quality. Sperm CFTR expression in fertile men is higher than that in infertile men suffering from teratospermia, asthenoteratospermia, asthenospermia and oligospermia, but it is unknown whether CFTR is correlated with sperm parameters when sperm parameters are normal. In this study, 282 healthy and fertile men with normal semen parameters were classified into three age groups, group (I): age group of 20–29 years (98 cases, 27.1 ± 6.2), group (II): age group of 30–39 years (142 cases, 33.7 ± 2.6) and group (III): age group of more than or equal to 40 years (42 cases, 44.1 ± 4.6). Sperm concentration, total count and progressive motility were analysed by computer‐assisted sperm analysis. Sperm morphology was analysed by modified Papanicolaou staining. Sperm CFTR expression was conducted by indirect immunofluorescence staining. There was a significant positive correlation (P  0.05). Our findings show that CFTR expression is associated with sperm progressive motility and normal morphology in healthy and fertile men with normal sperm parameters, but not associated with the number of spermatozoa and male age.
ISSN:0303-4569
1439-0272
DOI:10.1111/and.12155