Twin studies in keratoconus

Genetic determinants of keratoconus are still largely unknown. Over the last two decades there has been a shift from regarding keratoconus as a monogenic disease with variable expression towards a general consensus that it is most likely to be a multifactorial disorder with multiple genetic and envi...

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Bibliographic Details
Published in:Acta ophthalmologica (Oxford, England) England), 2014-09, Vol.92 (s253), p.0-0
Main Author: LISKOVA, P
Format: Article
Language:English
Subjects:
Ophthalmology
Twins
Online Access:Get full text
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Summary:Genetic determinants of keratoconus are still largely unknown. Over the last two decades there has been a shift from regarding keratoconus as a monogenic disease with variable expression towards a general consensus that it is most likely to be a multifactorial disorder with multiple genetic and environmental components​ contributing to its development. Twins are useful in assessing the heritability of traits. Discordant monozygotic twin pairs can be used to look for environmental and epigenetic factors. The contribution of twin studies to the understanding of keratoconus genetics will be discussed.
ISSN:1755-375X
1755-3768
DOI:10.1111/j.1755-3768.2014.2463.x