NOVEL ROLE OF ANTICOAGULANT HEPARAN SULFATE IN ANTITHROMBIN ANTI-INFLAMMATORY SIGNALING

Conversely AT treatment of Hs3st1-/- mice enhanced both LPS-induced lethality and leukocyte-endothelial interactions. [...]AT failed to elicit anti-inflammatory effects in mice lacking HSAT+.

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2012-03, Vol.59 (13), p.E2132-E2132
Main Author: Smits, Nicole C
Format: Article
Language:English
Subjects:
Anticoagulants
Cardiology
Cardiovascular
Gene expression
Heparan sulfate
Internal Medicine
Leukocytes
Rodents
Online Access:Get full text
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Description
Summary:Conversely AT treatment of Hs3st1-/- mice enhanced both LPS-induced lethality and leukocyte-endothelial interactions. [...]AT failed to elicit anti-inflammatory effects in mice lacking HSAT+.
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(12)62133-0