Insights Into Echo-Attenuated Plaques, Echolucent Plaques, and Plaques With Spotty Calcification

Objectives Three intravascular ultrasound (IVUS) signatures have been associated with coronary artery disease instability: echo attenuation, an intraplaque echolucent zone, and spotty calcification. The aim of this study was to investigate the substrates responsible for these IVUS signatures in a re...

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Published in:Journal of the American College of Cardiology 2014-06, Vol.63 (21), p.2220-2233
Main Authors: Pu, Jun, MD, Mintz, Gary S., MD, Biro, Sinan, MSc, Lee, Jin-Bae, MD, Sum, Stephen T., PhD, Madden, Sean P., PhD, Burke, Allen P., MD, Zhang, Pei, PhD, He, Ben, MD, Goldstein, James A., MD, Stone, Gregg W., MD, Muller, James E., MD, Virmani, Renu, MD, Maehara, Akiko, MD
Format: Article
Language:English
Subjects:
atherosclerosis
attenuated plaque
Cardiology
Cardiovascular
Cardiovascular disease
Chronic obstructive pulmonary disease
Coronary vessels
Family medical history
Fatalities
Heart
Heart attacks
Internal Medicine
intravascular ultrasound
Lipids
near-infrared spectroscopy
Spectrum analysis
spotty calcification
Studies
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Summary:Objectives Three intravascular ultrasound (IVUS) signatures have been associated with coronary artery disease instability: echo attenuation, an intraplaque echolucent zone, and spotty calcification. The aim of this study was to investigate the substrates responsible for these IVUS signatures in a relatively large series of post-mortem human coronary samples. Background The exact mechanisms and pathological correlates underlying echo attenuation, an intraplaque echolucent zone, and spotty calcification remain poorly understood. Methods IVUS was compared with near-infrared spectroscopic detection of lipid core plaque and histopathology in 2,294 vessel segments from 151 coronary specimens from 62 patients at necropsy using the modified American Heart Association classification. Results IVUS detected echo-attenuated plaques in 18.3% of segments, echolucent plaques in 10.5% of segments, and spotty calcification in 14.4% of segments. Histopathologically, 91.4% of echo-attenuated plaques corresponded to either a fibroatheroma (FA) with a necrotic core (NC) or pathological intimal thickening with a lipid pool; almost all segments with superficial echo attenuation indicated the presence of an FA with an advanced NC. Echolucent plaques indicated the presence of a relatively smaller lipid or NC compared with echo-attenuated plaques (thickness: 0.51 mm [interquartile range (IQR): 0.35 to 0.64 mm] vs. 0.70 mm [IQR: 0.54 to 0.92 mm] [p < 0.001]; arc: 74.5° [IQR: 59.0° to 101.0°] vs. 90° [IQR: 70.0° to 112.0°] [p < 0.001]), although 82.8% of superficial echolucent zones indicated an NC-containing FA. IVUS spotty calcification, especially when superficial in location (72.6%), was often associated with an FA with calcium deposits and had smaller arcs of calcium in the setting of FA compared with fibrocalcific plaques (37.5° [IQR: 23.0° to 53.0°] vs. 59.0° [IQR: 46.0° to 69.0°]; p < 0.001). Comparisons between IVUS and near-infrared spectroscopy revealed that echo-attenuated plaques contained the highest probability of near-infrared spectroscopy–derived lipid core plaque, followed by echolucent plaques and spotty calcifications. Conclusions This study demonstrated that echo-attenuated plaque, especially superficial echo attenuation, was the most reliable IVUS signature for identifying a high-risk plaque (i.e., an FA containing a large NC).
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2014.02.576