Ethanol-Induced Gastric Injury: Microscopic Analysis of the Protective Effect of Frutalin

Obtained from breadfruit seeds ( Artocarpus incisa ), frutalin (FTL) has a range of important pharmacological properties. FTL activates and modulates lymphocytes and neutrophils and possesses gastroprotective effects. The purpose of this study was to evaluate the ability of FTL to protect the gastri...

Full description

Saved in:
Bibliographic Details
Published in:International journal of peptide research and therapeutics 2014-09, Vol.20 (3), p.325-332
Main Authors: Abdon, Ana Paula Vasconcellos, Vasconcelos, Renata Prado, Castro, Carolina Araújo, Guedes, Marjorie Moreira, Tomé, Adriana da Rocha, Cardoso, André Luiz Herzog, Santiago, Thiago de Melo, Rebêlo, Luciana Magalhães, Moreira, Renato de Azevedo, Monteiro-Moreira, Ana Cristina de Oliveira, Campos, Adriana Rolim
Format: Article
Language:English
Subjects:
Animal Anatomy
Biochemistry
Biomedical and Life Sciences
Gastrointestinal diseases
Histology
Lectins
Life Sciences
Molecular Medicine
Morphology
Pharmaceutical Sciences/Technology
Pharmacology/Toxicology
Polymer Sciences
Rodents
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Obtained from breadfruit seeds ( Artocarpus incisa ), frutalin (FTL) has a range of important pharmacological properties. FTL activates and modulates lymphocytes and neutrophils and possesses gastroprotective effects. The purpose of this study was to evaluate the ability of FTL to protect the gastric mucosa of mice submitted to ethanol-induced gastric injury. The gastroprotective effect of frutalina was evaluated using a murine model of ethanol-induced gastric injury. Damage of the gastric mucosa was assessed morphologically by light, scanning electron and atomic force microscopy. Lymphocyte infiltration, necrosis, disruption of the mucosal structures and epithelial desquamation were observed in the control group. In the group pretreated with frutalina at 0.5 mg/kg, gastroprotection, reduced tissue damage and preserved submucosal and mucosal structures were observed. In conclusion, FTL displayed gastroprotective activity against ethanol-induced gastric injury, preventing the formation of gastric ulcer and reducing epithelial desquamation, glandular damage, mucosal necrosis and infiltration. The observed effects appear to be due to mechanisms previously described for frutalin.
ISSN:1573-3149
1573-3904
DOI:10.1007/s10989-014-9398-8