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A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels
Summary Objective Elevated plasma adrenomedullin (ADM) levels are associated with cardiovascular diseases. Single nucleotide polymorphisms (SNPs) in the gene encoding ADM (ADM) are associated with plasma ADM levels. The presence of a nuclear factor for interleukin‐6 (IL‐6) expression binding site in...
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| Published in: | Clinical endocrinology (Oxford) 2013-10, Vol.79 (4), p.504-509 |
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| container_title | Clinical endocrinology (Oxford) |
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| creator | Wong, Hoi Kin Ong, Kwok Leung Leung, Raymond Y. H. Lam, Tai Hing Thomas, Graham Neil Lam, Karen S. L. Cheung, Bernard M. Y. |
| description | Summary
Objective
Elevated plasma adrenomedullin (ADM) levels are associated with cardiovascular diseases. Single nucleotide polymorphisms (SNPs) in the gene encoding ADM (ADM) are associated with plasma ADM levels. The presence of a nuclear factor for interleukin‐6 (IL‐6) expression binding site in the promoter region of the ADM gene suggests a possible relationship between the expression of the ADM and IL‐6. Therefore, we investigated whether plasma ADM levels are related to SNPs in the gene encoding IL‐6 (IL6).
Methods
Plasma ADM levels were measured in 476 subjects in the Hong Kong Cardiovascular Risk Factor Prevalence Study‐2 (CRISPS2). The subjects were genotyped for three tagging SNPs in the IL6 gene.
Results
The minor allele frequencies of the IL6 SNPs rs17147230, rs1800796 and rs2069837 were 41·8%, 20·0% and 15·4%, respectively. The tagging SNP, rs17147230, was associated with plasma ADM levels after adjusting for age and sex (β=−0·096, P = 0·034). The association was significant in women (β=−0·115, P = 0·021) but not in men. Among all subjects, plasma ADM levels decreased with an increasing number of minor alleles of rs17147230 in multivariate analysis (P = 0·034). Compared to subjects with the AA genotype, subjects with the TT genotype had plasma ADM levels 12·8% lower (95% CI: 0·6–23·5%, P = 0·041). Haplotype analysis demonstrated a significant association of the haplotype ACA with plasma ADM levels in women (P |
| doi_str_mv | 10.1111/cen.12078 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1529570874</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3317546451</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4238-5f48f6667b1b51bc0f0f6f0e13dc5319ac4dd5f54f6edb3069a3506a8f5edae73</originalsourceid><addsrcrecordid>eNp1kU9v1DAQxS0EokvhwBdAlhAHDmnHcWxnj9WqFKpqkfh7tBxnXNw6TrATYL89ht2WE3OZy--9p3lDyHMGJ6zMqcV4wmpQ7QOyYlyKqq6leEhWwAEqkLI5Ik9yvgEA0YJ6TI5qDm1br8WKmDOafbwOSONiA46z75FOY9gNY5q--TzQ0VEfZ0wBl1sfK0mvMSL1mSYMZsaeziOdgsmDoaZPGMcB-yUEH2nAHxjyU_LImZDx2WEfk89vzj9t3lZX7y_ebc6uKtvUvK2Ea1onpVQd6wTrLDhw0gEy3lvB2drYpu-FE42T2Hcc5NpwAdK0TmBvUPFj8nLvO6Xx-4J51jfjkmKJ1EyUWxW0qinU6z1l05hzQqen5AeTdpqB_lOmLmXqv2UW9sXBcenKUffkXXsFeHUATLYmuGSi9fkfp-RagaoLd7rnfvqAu_8n6s359i662it8nvHXvcKkWy0VV0J_3V7oDx8vv2zLv_Ul_w0BUpr6</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1529570874</pqid></control><display><type>article</type><title>A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels</title><source>Wiley</source><creator>Wong, Hoi Kin ; Ong, Kwok Leung ; Leung, Raymond Y. H. ; Lam, Tai Hing ; Thomas, Graham Neil ; Lam, Karen S. L. ; Cheung, Bernard M. Y.</creator><creatorcontrib>Wong, Hoi Kin ; Ong, Kwok Leung ; Leung, Raymond Y. H. ; Lam, Tai Hing ; Thomas, Graham Neil ; Lam, Karen S. L. ; Cheung, Bernard M. Y.</creatorcontrib><description>Summary
Objective
Elevated plasma adrenomedullin (ADM) levels are associated with cardiovascular diseases. Single nucleotide polymorphisms (SNPs) in the gene encoding ADM (ADM) are associated with plasma ADM levels. The presence of a nuclear factor for interleukin‐6 (IL‐6) expression binding site in the promoter region of the ADM gene suggests a possible relationship between the expression of the ADM and IL‐6. Therefore, we investigated whether plasma ADM levels are related to SNPs in the gene encoding IL‐6 (IL6).
Methods
Plasma ADM levels were measured in 476 subjects in the Hong Kong Cardiovascular Risk Factor Prevalence Study‐2 (CRISPS2). The subjects were genotyped for three tagging SNPs in the IL6 gene.
Results
The minor allele frequencies of the IL6 SNPs rs17147230, rs1800796 and rs2069837 were 41·8%, 20·0% and 15·4%, respectively. The tagging SNP, rs17147230, was associated with plasma ADM levels after adjusting for age and sex (β=−0·096, P = 0·034). The association was significant in women (β=−0·115, P = 0·021) but not in men. Among all subjects, plasma ADM levels decreased with an increasing number of minor alleles of rs17147230 in multivariate analysis (P = 0·034). Compared to subjects with the AA genotype, subjects with the TT genotype had plasma ADM levels 12·8% lower (95% CI: 0·6–23·5%, P = 0·041). Haplotype analysis demonstrated a significant association of the haplotype ACA with plasma ADM levels in women (P < 0·05).
Conclusion
Plasma ADM levels are related to the SNP rs17147230 in IL6 gene. The effect of the polymorphism on inflammation and cardiovascular disease remains to be determined.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/cen.12078</identifier><identifier>PMID: 23088295</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford: Blackwell Publishing Ltd</publisher><subject>Adrenomedullin - blood ; Adult ; Asian Continental Ancestry Group - genetics ; Biological and medical sciences ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - ethnology ; Cardiovascular Diseases - genetics ; Endocrinopathies ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Frequency ; Genotype ; Haplotypes ; Hong Kong - epidemiology ; Humans ; Interleukin-6 - genetics ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Polymorphism, Single Nucleotide ; Prevalence ; Risk Factors ; Sex Factors ; Vertebrates: endocrinology</subject><ispartof>Clinical endocrinology (Oxford), 2013-10, Vol.79 (4), p.504-509</ispartof><rights>2012 John Wiley & Sons Ltd</rights><rights>2014 INIST-CNRS</rights><rights>2012 John Wiley & Sons Ltd.</rights><rights>Copyright © 2013 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4238-5f48f6667b1b51bc0f0f6f0e13dc5319ac4dd5f54f6edb3069a3506a8f5edae73</citedby><cites>FETCH-LOGICAL-c4238-5f48f6667b1b51bc0f0f6f0e13dc5319ac4dd5f54f6edb3069a3506a8f5edae73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcen.12078$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcen.12078$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27697072$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23088295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wong, Hoi Kin</creatorcontrib><creatorcontrib>Ong, Kwok Leung</creatorcontrib><creatorcontrib>Leung, Raymond Y. H.</creatorcontrib><creatorcontrib>Lam, Tai Hing</creatorcontrib><creatorcontrib>Thomas, Graham Neil</creatorcontrib><creatorcontrib>Lam, Karen S. L.</creatorcontrib><creatorcontrib>Cheung, Bernard M. Y.</creatorcontrib><title>A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol</addtitle><description>Summary
Objective
Elevated plasma adrenomedullin (ADM) levels are associated with cardiovascular diseases. Single nucleotide polymorphisms (SNPs) in the gene encoding ADM (ADM) are associated with plasma ADM levels. The presence of a nuclear factor for interleukin‐6 (IL‐6) expression binding site in the promoter region of the ADM gene suggests a possible relationship between the expression of the ADM and IL‐6. Therefore, we investigated whether plasma ADM levels are related to SNPs in the gene encoding IL‐6 (IL6).
Methods
Plasma ADM levels were measured in 476 subjects in the Hong Kong Cardiovascular Risk Factor Prevalence Study‐2 (CRISPS2). The subjects were genotyped for three tagging SNPs in the IL6 gene.
Results
The minor allele frequencies of the IL6 SNPs rs17147230, rs1800796 and rs2069837 were 41·8%, 20·0% and 15·4%, respectively. The tagging SNP, rs17147230, was associated with plasma ADM levels after adjusting for age and sex (β=−0·096, P = 0·034). The association was significant in women (β=−0·115, P = 0·021) but not in men. Among all subjects, plasma ADM levels decreased with an increasing number of minor alleles of rs17147230 in multivariate analysis (P = 0·034). Compared to subjects with the AA genotype, subjects with the TT genotype had plasma ADM levels 12·8% lower (95% CI: 0·6–23·5%, P = 0·041). Haplotype analysis demonstrated a significant association of the haplotype ACA with plasma ADM levels in women (P < 0·05).
Conclusion
Plasma ADM levels are related to the SNP rs17147230 in IL6 gene. The effect of the polymorphism on inflammation and cardiovascular disease remains to be determined.</description><subject>Adrenomedullin - blood</subject><subject>Adult</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - ethnology</subject><subject>Cardiovascular Diseases - genetics</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Hong Kong - epidemiology</subject><subject>Humans</subject><subject>Interleukin-6 - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Vertebrates: endocrinology</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1kU9v1DAQxS0EokvhwBdAlhAHDmnHcWxnj9WqFKpqkfh7tBxnXNw6TrATYL89ht2WE3OZy--9p3lDyHMGJ6zMqcV4wmpQ7QOyYlyKqq6leEhWwAEqkLI5Ik9yvgEA0YJ6TI5qDm1br8WKmDOafbwOSONiA46z75FOY9gNY5q--TzQ0VEfZ0wBl1sfK0mvMSL1mSYMZsaeziOdgsmDoaZPGMcB-yUEH2nAHxjyU_LImZDx2WEfk89vzj9t3lZX7y_ebc6uKtvUvK2Ea1onpVQd6wTrLDhw0gEy3lvB2drYpu-FE42T2Hcc5NpwAdK0TmBvUPFj8nLvO6Xx-4J51jfjkmKJ1EyUWxW0qinU6z1l05hzQqen5AeTdpqB_lOmLmXqv2UW9sXBcenKUffkXXsFeHUATLYmuGSi9fkfp-RagaoLd7rnfvqAu_8n6s359i662it8nvHXvcKkWy0VV0J_3V7oDx8vv2zLv_Ul_w0BUpr6</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Wong, Hoi Kin</creator><creator>Ong, Kwok Leung</creator><creator>Leung, Raymond Y. H.</creator><creator>Lam, Tai Hing</creator><creator>Thomas, Graham Neil</creator><creator>Lam, Karen S. L.</creator><creator>Cheung, Bernard M. Y.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>201310</creationdate><title>A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels</title><author>Wong, Hoi Kin ; Ong, Kwok Leung ; Leung, Raymond Y. H. ; Lam, Tai Hing ; Thomas, Graham Neil ; Lam, Karen S. L. ; Cheung, Bernard M. Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4238-5f48f6667b1b51bc0f0f6f0e13dc5319ac4dd5f54f6edb3069a3506a8f5edae73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adrenomedullin - blood</topic><topic>Adult</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - ethnology</topic><topic>Cardiovascular Diseases - genetics</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Haplotypes</topic><topic>Hong Kong - epidemiology</topic><topic>Humans</topic><topic>Interleukin-6 - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong, Hoi Kin</creatorcontrib><creatorcontrib>Ong, Kwok Leung</creatorcontrib><creatorcontrib>Leung, Raymond Y. H.</creatorcontrib><creatorcontrib>Lam, Tai Hing</creatorcontrib><creatorcontrib>Thomas, Graham Neil</creatorcontrib><creatorcontrib>Lam, Karen S. L.</creatorcontrib><creatorcontrib>Cheung, Bernard M. Y.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, Hoi Kin</au><au>Ong, Kwok Leung</au><au>Leung, Raymond Y. H.</au><au>Lam, Tai Hing</au><au>Thomas, Graham Neil</au><au>Lam, Karen S. L.</au><au>Cheung, Bernard M. Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol</addtitle><date>2013-10</date><risdate>2013</risdate><volume>79</volume><issue>4</issue><spage>504</spage><epage>509</epage><pages>504-509</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><notes>Sun Chieh Yeh Heart Foundation</notes><notes>University of Hong Kong</notes><notes>Table S1. Multivariate analysis of rs17147230 for plasma ADM levels (ln-transformed). Table S2. Association of haplotype with plasma ADM level in women.</notes><notes>Hong Kong Research Grants Council - No. HKU7626/07M; No. HKU7802/10M</notes><notes>ark:/67375/WNG-RSJVN136-J</notes><notes>istex:AB39EA49BD10CD878E3709145379A20641C6A6A8</notes><notes>ArticleID:CEN12078</notes><abstract>Summary
Objective
Elevated plasma adrenomedullin (ADM) levels are associated with cardiovascular diseases. Single nucleotide polymorphisms (SNPs) in the gene encoding ADM (ADM) are associated with plasma ADM levels. The presence of a nuclear factor for interleukin‐6 (IL‐6) expression binding site in the promoter region of the ADM gene suggests a possible relationship between the expression of the ADM and IL‐6. Therefore, we investigated whether plasma ADM levels are related to SNPs in the gene encoding IL‐6 (IL6).
Methods
Plasma ADM levels were measured in 476 subjects in the Hong Kong Cardiovascular Risk Factor Prevalence Study‐2 (CRISPS2). The subjects were genotyped for three tagging SNPs in the IL6 gene.
Results
The minor allele frequencies of the IL6 SNPs rs17147230, rs1800796 and rs2069837 were 41·8%, 20·0% and 15·4%, respectively. The tagging SNP, rs17147230, was associated with plasma ADM levels after adjusting for age and sex (β=−0·096, P = 0·034). The association was significant in women (β=−0·115, P = 0·021) but not in men. Among all subjects, plasma ADM levels decreased with an increasing number of minor alleles of rs17147230 in multivariate analysis (P = 0·034). Compared to subjects with the AA genotype, subjects with the TT genotype had plasma ADM levels 12·8% lower (95% CI: 0·6–23·5%, P = 0·041). Haplotype analysis demonstrated a significant association of the haplotype ACA with plasma ADM levels in women (P < 0·05).
Conclusion
Plasma ADM levels are related to the SNP rs17147230 in IL6 gene. The effect of the polymorphism on inflammation and cardiovascular disease remains to be determined.</abstract><cop>Oxford</cop><pub>Blackwell Publishing Ltd</pub><pmid>23088295</pmid><doi>10.1111/cen.12078</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adrenomedullin - blood Adult Asian Continental Ancestry Group - genetics Biological and medical sciences Cardiovascular Diseases - blood Cardiovascular Diseases - ethnology Cardiovascular Diseases - genetics Endocrinopathies Female Fundamental and applied biological sciences. Psychology Gene Frequency Genotype Haplotypes Hong Kong - epidemiology Humans Interleukin-6 - genetics Male Medical sciences Middle Aged Multivariate Analysis Polymorphism, Single Nucleotide Prevalence Risk Factors Sex Factors Vertebrates: endocrinology |
| title | A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels |
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