A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels

Summary Objective Elevated plasma adrenomedullin (ADM) levels are associated with cardiovascular diseases. Single nucleotide polymorphisms (SNPs) in the gene encoding ADM (ADM) are associated with plasma ADM levels. The presence of a nuclear factor for interleukin‐6 (IL‐6) expression binding site in...

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Published in:Clinical endocrinology (Oxford) 2013-10, Vol.79 (4), p.504-509
Main Authors: Wong, Hoi Kin, Ong, Kwok Leung, Leung, Raymond Y. H., Lam, Tai Hing, Thomas, Graham Neil, Lam, Karen S. L., Cheung, Bernard M. Y.
Format: Article
Language:English
Subjects:
Adrenomedullin - blood
Adult
Asian Continental Ancestry Group - genetics
Biological and medical sciences
Cardiovascular Diseases - blood
Cardiovascular Diseases - ethnology
Cardiovascular Diseases - genetics
Endocrinopathies
Female
Fundamental and applied biological sciences. Psychology
Gene Frequency
Genotype
Haplotypes
Hong Kong - epidemiology
Humans
Interleukin-6 - genetics
Male
Medical sciences
Middle Aged
Multivariate Analysis
Polymorphism, Single Nucleotide
Prevalence
Risk Factors
Sex Factors
Vertebrates: endocrinology
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Summary:Summary Objective Elevated plasma adrenomedullin (ADM) levels are associated with cardiovascular diseases. Single nucleotide polymorphisms (SNPs) in the gene encoding ADM (ADM) are associated with plasma ADM levels. The presence of a nuclear factor for interleukin‐6 (IL‐6) expression binding site in the promoter region of the ADM gene suggests a possible relationship between the expression of the ADM and IL‐6. Therefore, we investigated whether plasma ADM levels are related to SNPs in the gene encoding IL‐6 (IL6). Methods Plasma ADM levels were measured in 476 subjects in the Hong Kong Cardiovascular Risk Factor Prevalence Study‐2 (CRISPS2). The subjects were genotyped for three tagging SNPs in the IL6 gene. Results The minor allele frequencies of the IL6 SNPs rs17147230, rs1800796 and rs2069837 were 41·8%, 20·0% and 15·4%, respectively. The tagging SNP, rs17147230, was associated with plasma ADM levels after adjusting for age and sex (β=−0·096, P = 0·034). The association was significant in women (β=−0·115, P = 0·021) but not in men. Among all subjects, plasma ADM levels decreased with an increasing number of minor alleles of rs17147230 in multivariate analysis (P = 0·034). Compared to subjects with the AA genotype, subjects with the TT genotype had plasma ADM levels 12·8% lower (95% CI: 0·6–23·5%, P = 0·041). Haplotype analysis demonstrated a significant association of the haplotype ACA with plasma ADM levels in women (P 
ISSN:0300-0664
1365-2265
DOI:10.1111/cen.12078