Synthesis of 1,3,4-Oxadiazole-Based Aromatic and Heterocyclic/Phenylpyrazole Derivatives

ABSTRACT A new series of 1,3,4‐oxadiazole‐based aromatic and heterocyclic/phenylpyrazole derivatives 6a–c, 7a–d, and 8 were synthesized via sequential 1,3‐dipolar cyclization, hydrazidation, benzoylation, dehydrative cyclization, and the Suzuki coupling reaction. Among the derivatives, compounds 7a...

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Published in:Heteroatom chemistry 2014-05, Vol.25 (3), p.171-177
Main Authors: Wang, Li-Ya, Chang, En-Chiuan, Yeh, Mou-Yung, Chung, Yu Hsuan, Huang, Jiann-Jyh, Wong, Fung Fuh
Format: Article
Language:English
Subjects:
Derivatives
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Summary:ABSTRACT A new series of 1,3,4‐oxadiazole‐based aromatic and heterocyclic/phenylpyrazole derivatives 6a–c, 7a–d, and 8 were synthesized via sequential 1,3‐dipolar cyclization, hydrazidation, benzoylation, dehydrative cyclization, and the Suzuki coupling reaction. Among the derivatives, compounds 7a and 7c with the corresponding 2‐thienyl and 2‐benzo[b]thienyl (Ar) at the phenyl group located at the N‐1 position of pyrazole showed a better conjugation range.
ISSN:1042-7163
1098-1071
DOI:10.1002/hc.21151