Anti-rotavirus effects by combination therapy of stevioside andSophora flavescensextract

Anti-rotaviral activities ofSophora flavescensextract (SFE) and stevioside (SV) fromStevia rebaudianaBertoni either singly or in various combinations were examinedin vitroandin vivousing a porcine rotavirus G5[P7] strain. Combination of SFE and SV inhibitedin vitrovirus replication more efficiently...

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Bibliographic Details
Published in:Research in veterinary science 2014-06, Vol.96 (3), p.567
Main Authors: Alfajaro, Mia Madel, Rho, Mun-Chual, Kim, Hyun-Jeong, Park, Jun-Gyu, Kim, Deok-Song, Hosmillo, Myra, Son, Kyu-Yeol, Lee, Ju-Hwan, Park, Sang-Ik, Kang, Mun-Il, Ryu, Young Bae, Park, Ki Hun, Oh, Hyun-Mee, Lee, Seung Woong, Park, Su-Jin, Lee, Woo Song, Cho, Kyoung-Oh
Format: Article
Language:English
Subjects:
Candidates
Cell culture
Chinese medicine
Disease
Infections
Studies
Veterinary medicine
Viruses
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Summary:Anti-rotaviral activities ofSophora flavescensextract (SFE) and stevioside (SV) fromStevia rebaudianaBertoni either singly or in various combinations were examinedin vitroandin vivousing a porcine rotavirus G5[P7] strain. Combination of SFE and SV inhibitedin vitrovirus replication more efficiently than each single treatment. In the piglet model, SV had no effect on rotavirus enteritis, whereas SFE improved but did not completely cure rotaviral enteritis. Interestingly, combination therapy of SFE and SV alleviated diarrhea, and markedly improved small intestinal lesion score and fecal virus shedding. Acute toxicity tests including the piglet lethal dose 50, and body weight, organ weight and pathological changes for the combination therapy did not show any adverse effect on the piglets. These preliminary data suggest that the combination therapy of SV and SFE is a potential curative medication for rotaviral diarrhea in pigs. Determination of the efficacy of this combination therapy in other species including humans needs to be addressed in the future.
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2014.03.011