Base-Catalyzed NN Bond Cleavage of Hydrazones: Synthesis of [alpha]-Amino Ketones

An efficient Cs2CO3-promoted synthesis of [alpha]-amino ketones using hydrazines, aldehydes, and [alpha]-haloketones as starting materials through a cascade condensation/nucleophilic substitution/NN bond cleavage route is developed. The carbonyl group plays a key role in this novel NN bond cleavage...

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Bibliographic Details
Published in:Chemistry, an Asian journal an Asian journal, 2014-05, Vol.9 (5), p.1278
Main Authors: Tang, Hai-Tao, Zhou, Yun-Bing, Zhu, Yu, Sun, Hong-Chao, Lin, Min, Zhan, Zhuang-Ping
Format: Article
Language:English
Subjects:
Chemistry
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Summary:An efficient Cs2CO3-promoted synthesis of [alpha]-amino ketones using hydrazines, aldehydes, and [alpha]-haloketones as starting materials through a cascade condensation/nucleophilic substitution/NN bond cleavage route is developed. The carbonyl group plays a key role in this novel NN bond cleavage process. [PUBLICATION ABSTRACT]
ISSN:1861-4728
1861-471X
DOI:10.1002/asia.201400037