Hemichorea in a thymoma patient without anti-CRMP-5 antibody

We reported a 72-year-old man with thymoma who presented with hemichorea. Although his brain CT and MRI revealed no abnormality, regional cerebral blood flow changes, identified by single photon emission computed tomography, suggested that the mechanism underlying the chorea seemed to be a dysfuncti...

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Bibliographic Details
Published in:Neurological sciences 2014-04, Vol.35 (4), p.629-630
Main Authors: Nakae, Yoshiharu, Ikeda, Shingo, Yamamoto, Ryoo, Tanaka, Fumiaki, Johkura, Ken
Format: Article
Language:English
Subjects:
Aged
Antibodies
Chorea - complications
Chorea - diagnosis
Chorea - immunology
Humans
Letter to the Editor
Male
Medicine
Medicine & Public Health
Nerve Tissue Proteins - immunology
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Psychiatry
Thymoma - complications
Thymoma - diagnosis
Thymus Neoplasms - complications
Thymus Neoplasms - diagnosis
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Summary:We reported a 72-year-old man with thymoma who presented with hemichorea. Although his brain CT and MRI revealed no abnormality, regional cerebral blood flow changes, identified by single photon emission computed tomography, suggested that the mechanism underlying the chorea seemed to be a dysfunction of the subthalamic nucleus and pallidum. His hemichorea was completely resolved after thymectomy. Absence of serum anti-neural autoantibodies, including small-cell lung carcinoma-related chorea anti-CRMP-5 antibody, suggests that mechanisms different from cross-talk neural-targeted tumor immune response can be responsible for the thymoma-associated paraneoplastic chorea.
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-014-1629-4