Box 1. Differential regulation of CD27 and CCR7 expression in T-cell differentiation due to functional differences

Despite readily detectable virus-specific CD8+T cells in most HIV-infected patients, immune surveillance is eventually lost, leading to progression to AIDS. Recently developed insights into human T-cell differentiation have been used to study the phenotype of virus-specific T cells in HIV-infected i...

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Bibliographic Details
Published in:Trends in immunology 2002-12, Vol.23 (12), p.586
Main Authors: van Baarle, Debbie, Kostense, Stefan, van Oers, Marinus HJ, Hamann, Dorte, Miedema, Frank
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
HIV
Human immunodeficiency virus
Immune system
Infections
T cell receptors
Viral infections
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Summary:Despite readily detectable virus-specific CD8+T cells in most HIV-infected patients, immune surveillance is eventually lost, leading to progression to AIDS. Recently developed insights into human T-cell differentiation have been used to study the phenotype of virus-specific T cells in HIV-infected individuals. Based on these results, we propose that failing immune control in human viral infection could be a result of impaired cytotoxic T-lymphocyte (CTL) maturation into fully differentiated effector T cells. Impaired maturation is not confined to HIV-specific CD8+T cells but could also be involved in failing immunity to Epstein-Barr virus and other viral infections. We postulate that CD27-effector CD8+T cells might be required for adequate control of chronic viral infection and prevention of disease development.
ISSN:1471-4906
1471-4981
DOI:10.1016/S1471-4906(02)02326-8