Imaging Biomarkers of Aortic Disease

A sizable portion of patients with BAV and eccentric systolic flow do not have any measurable aortic stenosis (2), including 4 of 10 patients in this study, and thus would not be identified as at risk of post-stenotic dilation by echocardiography. [...]the 3-dimensional assessment of wall shear stre...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2012-07, Vol.60 (4), p.356-357
Main Authors: Hope, Michael D., MD, Wrenn, Jarrett, MD, PhD, Sigovan, Monica, PhD, Foster, Elyse, MD, Tseng, Elaine E., MD, Saloner, David, PhD
Format: Article
Language:English
Subjects:
Biomarkers
Cardiology
Cardiovascular
Coronary vessels
Internal Medicine
Medical imaging
Regression analysis
Shear stress
Studies
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Summary:A sizable portion of patients with BAV and eccentric systolic flow do not have any measurable aortic stenosis (2), including 4 of 10 patients in this study, and thus would not be identified as at risk of post-stenotic dilation by echocardiography. [...]the 3-dimensional assessment of wall shear stress and flow displacement that we report is only achieved with multidirectional phase-contrast CMR imaging. [...]the fact that hemodynamic biomarkers can be imaged noninvasively and potentially identify aortic disease well before clinical manifestation is an attractive goal that could meaningfully improve the clinical management of patients with aortic valve disease.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2012.01.072