Impact of QRS Duration and Morphology on the Risk of Sudden Cardiac Death in Asymptomatic Patients With Aortic Stenosis

Objectives The aim of the study was to examine the predictive value of QRS duration and morphology during watchful waiting in asymptomatic patients with aortic stenosis (AS). Background QRS duration and morphology are associated with poor prognosis in many different populations, but the predictive v...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2012-03, Vol.59 (13), p.1142-1149
Main Authors: Greve, Anders M., MD, Gerdts, Eva, MD, PhD, Boman, Kurt, MD, PhD, Gohlke-Baerwolf, Christa, MD, Rossebø, Anne B., MD, Devereux, Richard B., MD, Køber, Lars, MD, Ray, Simon, MD, Willenheimer, Ronnie, MD, PhD, Wachtell, Kristian, MD, PhD
Format: Article
Language:English
Subjects:
asymptomatic aortic stenosis
Cardiology
Cardiovascular
Electrocardiography
Heart attacks
Internal Medicine
Mortality
QRS duration
Studies
sudden cardiac death
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Summary:Objectives The aim of the study was to examine the predictive value of QRS duration and morphology during watchful waiting in asymptomatic patients with aortic stenosis (AS). Background QRS duration and morphology are associated with poor prognosis in many different populations, but the predictive value, particularly of the risk of sudden cardiac death (SCD), in asymptomatic patients with AS has not been well studied. Methods Data were obtained in asymptomatic AS patients randomized to simvastatin/ezetimibe combination versus placebo in the SEAS (Simvastatin and Ezetimibe in Aortic Stenosis) study. The impact of QRS duration, evaluated as a categorical variable of
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2011.12.020