Interaction of Caffeine With Regadenoson-Induced Hyperemic Myocardial Blood Flow as Measured by Positron Emission Tomography: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial

[...]it seems that caffeine blunts the vasodilatory effect of adenosine but has a limited effect on regadenoson. The interaction of caffeine with adenosine-induced, dipyridamole-induced, and even exercise-induced MBF changes (4,6) may limit the correct detection of coronary artery disease and subseq...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2008-01, Vol.51 (3), p.328-329
Main Authors: Gaemperli, Oliver, Schepis, Tiziano, Koepfli, Pascal, Siegrist, Patrick T., Fleischman, Samuel, Nguyen, Patricia, Olmsted, Ann, Wang, Whedy, Lieu, Hsiao, Kaufmann, Philipp A.
Format: Article
Language:English
Subjects:
Adenosine A2 Receptor Agonists
Adenosine A2 Receptor Antagonists
Blood pressure
Caffeine - pharmacology
Cardiology
Cardiovascular disease
Coronary Circulation - drug effects
Coronary vessels
Cross-Over Studies
Double-Blind Method
Drug Interactions
Heart Rate - drug effects
Humans
Medical research
Positron-Emission Tomography
Purines - pharmacology
Pyrazoles - pharmacology
Tomography
Vasodilator Agents - pharmacology
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Summary:[...]it seems that caffeine blunts the vasodilatory effect of adenosine but has a limited effect on regadenoson. The interaction of caffeine with adenosine-induced, dipyridamole-induced, and even exercise-induced MBF changes (4,6) may limit the correct detection of coronary artery disease and subsequently the proper management of the patient, leading to the general recommendation to withhold caffeine for 24 h before vasodilator stress testing (3). Because the hyperemic MBF response to regadenoson after caffeine administration lies well within the range of reported response to nonselective adenosine receptor agonists and bicycle stress (6), the present study suggests that regadenoson causes coronary hyperemia with and without prior caffeine ingestion in healthy volunteers and moderate caffeine consumption may not interfere with regadenoson stress MPI.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2007.10.014