IgE antibody responses induced in mice by protein allergens: Influence of bacterial endotoxin

The endotoxin content of protein allergen preparations has been suggested to influence the quality of immune responses. [...]intranasal exposure of mice to ovalbumin (OVA) with low levels of endotoxin (0.1μg/mouse) enhanced type 2 responses, whereas high dose endotoxin (100μg/mouse) resulted in a...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2005-02, Vol.115 (2), p.S166-S166
Main Authors: Dearman, R.J., Fox, D., Attenborough, S., Kimber, I.
Format: Article
Language:English
Subjects:
Allergies
Medical research
Proteins
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Summary:The endotoxin content of protein allergen preparations has been suggested to influence the quality of immune responses. [...]intranasal exposure of mice to ovalbumin (OVA) with low levels of endotoxin (0.1μg/mouse) enhanced type 2 responses, whereas high dose endotoxin (100μg/mouse) resulted in a selective type 1 response.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2004.12.676