Release-Dependent Variations in Synaptic Latency: A Putative Code for Short- and Long-Term Synaptic Dynamics

In the cortex, synaptic latencies display small variations (∼1–2 ms) that are generally considered to be negligible. We show here that the synaptic latency at monosynaptically connected pairs of L5 and CA3 pyramidal neurons is determined by the presynaptic release probability ( Pr): synaptic latency...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2007-12, Vol.56 (6), p.1048-1060
Main Authors: Boudkkazi, Sami, Carlier, Edmond, Ankri, Norbert, Caillard, Olivier, Giraud, Pierre, Fronzaroli-Molinieres, Laure, Debanne, Dominique
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Brain
Cerebral Cortex - cytology
Computer Simulation
Dose-Response Relationship, Radiation
Electric Stimulation
Excitatory Amino Acid Antagonists - pharmacology
Hypotheses
In Vitro Techniques
Male
Models, Neurological
Neuronal Plasticity - drug effects
Neuronal Plasticity - physiology
Neuronal Plasticity - radiation effects
Neurons
Neurons - physiology
Noise
Nonlinear Dynamics
Patch-Clamp Techniques
Quinoxalines - pharmacology
Rats
Rats, Wistar
Reaction Time - drug effects
Reaction Time - physiology
Reaction Time - radiation effects
Synapses - physiology
Synaptic Transmission - drug effects
Synaptic Transmission - physiology
Synaptic Transmission - radiation effects
SYSNEURO
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Summary:In the cortex, synaptic latencies display small variations (∼1–2 ms) that are generally considered to be negligible. We show here that the synaptic latency at monosynaptically connected pairs of L5 and CA3 pyramidal neurons is determined by the presynaptic release probability ( Pr): synaptic latency being inversely correlated with the amplitude of the postsynaptic current and sensitive to manipulations of Pr. Changes in synaptic latency were also observed when Pr was physiologically regulated in short- and long-term synaptic plasticity. Paired-pulse depression and facilitation were respectively associated with increased and decreased synaptic latencies. Similarly, latencies were prolonged following induction of presynaptic LTD and reduced after LTP induction. We show using the dynamic-clamp technique that the observed covariation in latency and synaptic strength is a synergistic combination that significantly affects postsynaptic spiking. In conclusion, amplitude-related variation in latency represents a putative code for short- and long-term synaptic dynamics in cortical networks.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2007.10.037