Physical activity affects plasma coenzyme Q^sub 10^ levels differently in young and old humans

Coenzyme Q (Q) is a key lipidic compound for cell bioenergetics and membrane antioxidant activities. It has been shown that also has a central role in the prevention of oxidation of plasma lipoproteins. Q has been associated with the prevention of cholesterol oxidation and several aging-related dise...

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Bibliographic Details
Published in:Biogerontology (Dordrecht) 2014-04, Vol.15 (2), p.199
Main Authors: Del Pozo-cruz, Jesús, Rodríguez-bies, Elisabet, Ballesteros-simarro, Manuel, Navas-enamorado, Ignacio, Tung, Bui Thanh, Navas, Plácido, López-lluch, Guillermo
Format: Article
Language:English
Subjects:
Aging
Antioxidants
Cholesterol
Diabetes
Disease prevention
Exercise
Lipid peroxidation
Lipids
Membranes
Musculoskeletal system
Older people
Oxidation
Physical fitness
Physiology
Plasma
Questionnaires
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Summary:Coenzyme Q (Q) is a key lipidic compound for cell bioenergetics and membrane antioxidant activities. It has been shown that also has a central role in the prevention of oxidation of plasma lipoproteins. Q has been associated with the prevention of cholesterol oxidation and several aging-related diseases. However, to date no clear data on the levels of plasma Q during aging are available. We have measured the levels of plasmatic Q^sub 10^ and cholesterol in young and old individuals showing different degrees of physical activity. Our results indicate that plasma Q^sub 10^ levels in old people are higher that the levels found in young people. Our analysis also indicates that there is no a relationship between the degree of physical activity and Q^sub 10^ levels when the general population is studied. However, very interestingly, we have found a different tendency between Q^sub 10^ levels and physical activity depending on the age of individuals. In young people, higher activity correlates with lower Q^sub 10^ levels in plasma whereas in older adults this ratio changes and higher activity is related to higher plasma Q^sub 10^ levels and higher Q^sub 10^/Chol ratios. Higher Q^sub 10^ levels in plasma are related to lower lipoperoxidation and oxidized LDL levels in elderly people. Our results highlight the importance of life habits in the analysis of Q^sub 10^ in plasma and indicate that the practice of physical activity at old age can improve antioxidant capacity in plasma and help to prevent cardiovascular diseases.[PUBLICATION ABSTRACT]
ISSN:1389-5729
1573-6768
DOI:10.1007/s10522-013-9491-y