Boromycin, an Anti-HIV Antibiotic

The polyether-macrolide antibiotic, boromycin, was isolated as a potent anti-human immunodeficiency virus (HIV) antibiotic from a fermentation broth of Streptomyces sp. A-3376. Boromycin was found to strongly inhibit the replication of the clinically isolated HIV-1 strain as well as the cultured str...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1996, Vol.60 (6), p.1036-1037
Main Authors: Kohno, Jun, Kawahata, Takuya, Otake, Toru, Morimoto, Motoko, Mori, Haruyo, Ueba, Noboru, Nishio, Maki, Kinumaki, Akio, Komatsubara, Saburo, Kawashima, Keisuke
Format: Article
Language:English
Subjects:
1-Deoxynojirimycin - analogs & derivatives
AIDS/HIV
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
anti-HIV
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Applied microbiology
Biological and medical sciences
Biotechnology
Borates - chemistry
Borates - pharmacology
boromycin
Cell Line
Dextran Sulfate - pharmacology
Fundamental and applied biological sciences. Psychology
Glucosamine - analogs & derivatives
Glucosamine - pharmacology
Glycoside Hydrolases - antagonists & inhibitors
HIV Reverse Transcriptase
HIV-1 - drug effects
HIV-2 - drug effects
human immunodeficiency virus
Humans
Medical sciences
Microbiology
Molecular Structure
Pharmacology. Drug treatments
RNA-Directed DNA Polymerase - drug effects
RNA-Directed DNA Polymerase - metabolism
Streptomyces
Streptomyces - metabolism
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Summary:The polyether-macrolide antibiotic, boromycin, was isolated as a potent anti-human immunodeficiency virus (HIV) antibiotic from a fermentation broth of Streptomyces sp. A-3376. Boromycin was found to strongly inhibit the replication of the clinically isolated HIV-1 strain as well as the cultured strain in in vitro laboratory experiments. The mechanism for the anti-HIV activity of boromycin is suggested to involve blocking the later stage of HIV infection, and probably the maturity step for replication of the HIV molecule.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.60.1036