Correlation between Flavonoid Content and the NO Production Inhibitory Activity of Peel Extracts from Various Citrus Fruits

We investigated the correlation between the flavonoid content and NO production inhibitory activity of fruit peel extracts using 20 citrus plants. The contents of seven flavonoids (naringin, naringenin, hesperidin, hesperetin, rutin, nobiletin, and tangeretin) were determined by HPLC analysis. Each...

Full description

Saved in:
Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2007, Vol.30(4), pp.772-778
Main Authors: Choi, Soo-Youn, Ko, Hee-Chul, Ko, Soo-Youn, Hwang, Joon-Ho, Park, Ji-Gweon, Kang, Shin-Hae, Han, Sang-Hun, Yun, Su-Hyun, Kim, Se-Jae
Format: Article
Language:English
Subjects:
Animals
Cell Line
Cell Survival - drug effects
Chromatography, High Pressure Liquid
Citrus - chemistry
Citrus - classification
citrus peel
Dose-Response Relationship, Drug
flavonoid
Flavonoids - analysis
Flavonoids - chemistry
Flavonoids - metabolism
Flavonoids - pharmacology
Fruit - chemistry
Inhibitory Concentration 50
Liposomes - pharmacology
Macrophages - chemistry
Macrophages - drug effects
Mice
Molecular Structure
nitric oxide (NO) production inhibitory activity
Nitric Oxide - antagonists & inhibitors
Nitric Oxide - biosynthesis
Nitrites - analysis
nobiletin
Plant Extracts - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We investigated the correlation between the flavonoid content and NO production inhibitory activity of fruit peel extracts using 20 citrus plants. The contents of seven flavonoids (naringin, naringenin, hesperidin, hesperetin, rutin, nobiletin, and tangeretin) were determined by HPLC analysis. Each citrus peel extract varied in flavonoid content, but the contents of nobiletin and tangeretin, which were contained in all 20 fruit peels, showed a positive and significant correlation with each other (r=0.879, p
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.30.772