The Essential Oil from Angelica gigas NAKAI Suppresses Nicotine Sensitization

Behavioral sensitization, as evidenced by the progressive enhanced locomotor response to a subsequent injection of the drug, is the major behavioral outcome produced by repeated injections of nicotine, and a model for studying drug addiction. It is putatively regarded that the alteration of extracel...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2005, Vol.28(12), pp.2323-2326
Main Authors: Zhao, Rong Jie, Koo, Byung Soo, Kim, Geun Woo, Jang, Eun Young, Lee, Jong Rok, Kim, Mi Ryeo, Kim, Sang Chan, Kwon, Young Kyu, Kim, Kwang Joong, Huh, Tae-lin, Kim, Dae-Hyun, Shim, Insop, Yang, Chae Ha
Format: Article
Language:eng ; jpn
Subjects:
Administration, Inhalation
Angelica
Angelica gigas
Animals
aromatherapy
Aromatherapy - methods
dopamine
Dopamine - chemistry
Dopamine - metabolism
Drug Administration Schedule
essential oil
Injections, Subcutaneous
locomotor activity
Male
Mentha - chemistry
Motor Activity - drug effects
nicotine
Nicotine - administration & dosage
Nicotine - adverse effects
Nucleus Accumbens - chemistry
Nucleus Accumbens - drug effects
Nucleus Accumbens - metabolism
Oils, Volatile - administration & dosage
Oils, Volatile - pharmacology
Plant Leaves - chemistry
Plant Roots - chemistry
Plant Stems - chemistry
Rats
Rats, Sprague-Dawley
Tobacco Use Disorder - physiopathology
Tobacco Use Disorder - prevention & control
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Summary:Behavioral sensitization, as evidenced by the progressive enhanced locomotor response to a subsequent injection of the drug, is the major behavioral outcome produced by repeated injections of nicotine, and a model for studying drug addiction. It is putatively regarded that the alteration of extracellular dopamine release in the nucleus accumbens is closely associated with nicotine-induced behavioral sensitization. The present study was performed to evaluate the effects of the essential oil from Angelica gigas NAKAI (on fragrance inhalation) on repeated nicotine-induced locomotor activity and extracellular dopamine levels in the nucleus accumbens of rats using in vivo microdialysis. Rats were given repeated injections of saline or nicotine (0.4 mg/kg s.c., twice a day for 7 d), followed by one challenge injection on the 4th day after the last daily injection. Systemic challenge with nicotine (0.4 mg/kg s.c.) produced a larger increase in locomotor activity in nicotine-pretreated rats than in saline-pretreated rats. A direct local challenge of 3 mM nicotine via a microdialysis probe also induced a larger increase in dopamine release in nicotine-pretreated rats than in saline-pretreated rats. Most importantly, our results showed that inhalation of the essential oils from Angelica gigas NAKAI significantly decreased both dopamine release in the nucleus accumbens and locomotor activity induced by a nicotine challenge. These results suggest that the essential oils from Angelica gigas NAKAI inhibit nicotine-induced behavioral and neurochemical sensitization, and imply that the essential oil from Angelica gigas NAKAI may be effective in treating nicotine addiction, possibly by modulating dopamine release in the nucleus accumbens.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.28.2323