Combined toxicity of penicillin and aspirin therapy may elicit bilateral vestibulopathy

[...]aspirin has been found to modulate cochlear neurotoxicity of gentamicin, but an interaction between aspirin and penicillin has not been examined yet. [...]ampicillin and NSAIDs have been shown to compete for protein binding. [...]penicillin may elevate the free serum concentrations of NSAIDs an...

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Bibliographic Details
Published in:Clinical neurology and neurosurgery 2013-07, Vol.115 (7), p.1114-1116
Main Authors: Hertel, S, Schwaninger, M, Helmchen, C
Format: Article
Language:English
Subjects:
Aged
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - therapeutic use
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Aspirin
Aspirin - adverse effects
Aspirin - therapeutic use
Ataxia
Bilateral vestibulopathy
Drug dosages
Electronystagmography
Female
Gait Disorders, Neurologic - etiology
Humans
Irrigation
Male
Medical treatment
Neurologic Examination
Neurology
Neurosurgery
NSAIDs
Patients
Penicillin
Penicillins - adverse effects
Penicillins - therapeutic use
Pyridines - adverse effects
Pyridines - therapeutic use
Reflex, Vestibulo-Ocular - physiology
Street signs
Studies
Sulfones - adverse effects
Sulfones - therapeutic use
Toxicity
Tumors
Vertigo
Vestibular Diseases - chemically induced
Vestibular Diseases - physiopathology
Vestibular Evoked Myogenic Potentials - physiology
Vestibular Function Tests
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Description
Summary:[...]aspirin has been found to modulate cochlear neurotoxicity of gentamicin, but an interaction between aspirin and penicillin has not been examined yet. [...]ampicillin and NSAIDs have been shown to compete for protein binding. [...]penicillin may elevate the free serum concentrations of NSAIDs and enhance their toxicity.
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2012.08.033