Fifteen different ^sup 18^F-FDG PET/CT qualitative and quantitative parameters investigated as pathological response predictors of locally advanced rectal cancer treated by neoadjuvant chemoradiation therapy

The aim of this study was to correlate qualitative visual response and various PET quantification factors with the tumour regression grade (TRG) classification of pathological response to neoadjuvant chemoradiotherapy (CRT) proposed by Mandard. Included in this retrospective study were 69 consecutiv...

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Published in:European journal of nuclear medicine and molecular imaging 2013-06, Vol.40 (6), p.853
Main Authors: Maffione, Anna Margherita, Ferretti, Alice, Grassetto, Gaia, Bellan, Elena, Capirci, Carlo, Chondrogiannis, Sotirios, Gava, Marcello, Marzola, Maria Cristina, Rampin, Lucia, Bondesan, Claudia, Colletti, Patrick M, Rubello, Domenico
Format: Article
Language:English
Subjects:
Chemotherapy
Kidney cancer
Parameter estimation
Pathology
Qualitative research
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Summary:The aim of this study was to correlate qualitative visual response and various PET quantification factors with the tumour regression grade (TRG) classification of pathological response to neoadjuvant chemoradiotherapy (CRT) proposed by Mandard. Included in this retrospective study were 69 consecutive patients with locally advanced rectal cancer (LARC). FDG PET/CT scans were performed at staging and after CRT (mean 6.7 weeks). Tumour SUVmax and its related arithmetic and percentage decrease (response index, RI) were calculated. Qualitative analysis was performed by visual response assessment (VRA), PERCIST 1.0 and response cut-off classification based on a new definition of residual disease. Metabolic tumour volume (MTV) was calculated using a 40 % SUVmax threshold, and the total lesion glycolysis (TLG) both before and after CRT and their arithmetic and percentage change were also calculated. We split the patients into responders (TRG 1 or 2) and nonresponders (TRG 3-5). SUVmax MTV and TLG after CRT, RI, [Delta]MTV% and [Delta]TLG% parameters were significantly correlated with pathological treatment response (p
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-013-2357-3