Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer: e1001183

The considerable uncertainty regarding cancer risks associated with inherited mutations of BRCA2 is due to unknown factors. To investigate whether common genetic variants modify penetrance for BRCA2 mutation carriers, we undertook a two-staged genome-wide association study in BRCA2 mutation carriers...

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Published in:	PLoS genetics 2010-10, Vol.6 (10)
Main Authors:	Kirchhoff, Tomas, Green, Todd, Vijai, Joseph, Korn, Joshua M, Guiducci, Candace, Segrè, Ayellet V, McGee, Kate, McGuffog, Lesley, Healey, Sue, Stoppa-Lyonnet, Dominique, Gauthier-Villars, Marion, Sobol, Hagay, Longy, Michel, Collaborators, GEMO Study, Hogervorst, Frans BL, Collée, J Margriet, Hoogerbrugge, Nicoline, Roozendaal, E Pvan, Piedmonte, Marion, Rubinstein, Wendy, Nerenstone, Stacy, Le, Linda Van, Blank, Stephanie V, Hoya, Miguel dela, Nevanlinna, Heli, Aittomäki, Kristiina, Blanco, Ignacio, Arason, Adalgeir, Johannsson, Oskar T, Barkardottir, Rosa B, Devilee, Peter, Olopade, Olofunmilayo I, Neuhausen, Susan L, Wang, Xianshu, Fredericksen, Zachary S, Manoukian, Siranoush, Barile, Monica, Viel, Alessandra, Radice, Paolo, Phelan, Catherine M, Narod, Steven, Lejbkowicz, Flavio, Flugelman, Anath, Andrulis, Irene L, Glendon, Gord, Ozcelik, Hilmi, Toland, Amanda E, Montagna, Marco, Friedman, Eitan, Borg, Ake, Beattie, Mary, Ramus, Susan J, Domchek, Susan M, Nathanson, Katherine L, Rebbeck, Tim, Spurdle, Amanda B, Chen, Xiaoqing, Holland, Helene, John, Esther M, Hopper, John L, Buys, Saundra S, Daly, Mary B, Southey, Melissa C, Terry, Mary Beth, Tung, Nadine, Hansen, Thomas VOvereem, Nielsen, Finn C, Greene, Mark I, Mai, Phuong L, Osorio, Ana, Durán, Mercedes, Andres, Raquel, Benítez, Javier, Weitzel, Jeffrey N, Hamann, Ute, Cook, Margaret, Oliver, Clare, Frost, Debra, Platte, Radka, Evans, D Gareth, Eeles, Ros, Izatt, Louise, Walker, Lisa, Eason, Jacqueline, Barwell, Julian, Godwin, Andrew K, Schmutzler, Rita K, Wappenschmidt, Barbara, Engert, Stefanie, Arnold, Norbert, Gadzicki, Dorothea, Dean, Michael, Gold, Bert, Couch, Fergus J, Chenevix-Trench, Georgia, Easton, Douglas F, Daly, Mark J, Antoniou, Antonis C, Offit, Kenneth, Collaborators, HEBON Study
Format:	Article
Language:	English
Subjects:	Breast cancer Chromosomes Confidence intervals Genealogy Genomes Medical research Mutation Population Quality control
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