Synthesis and Characterization of Related Substances of Deferasirox, an Iron (Fe3+) Chelating Agent

Deferasirox is an orally active iron chelating agent, and during process development for deferasirox, we observed six related substances (impurities), namely deferasirox methyl ester, deferasirox salicylyl derivative, deferasirox ethyl ester, deferasirox methoxy carbonyl derivative, bis(salicyl)imid...

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Bibliographic Details
Published in:Synthetic communications 2012-11, Vol.42 (21), p.3200-3210
Main Authors: Rao, Vascuri Janardhana, Mukkanti, Kagga, Vekariya, N. A., Gupta, P. Badrinadh, Islam, Aminul
Format: Article
Language:English
Subjects:
chelating agent
Deferasirox
iron (Fe
Preventive maintenance
related substances and synthesis
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Summary:Deferasirox is an orally active iron chelating agent, and during process development for deferasirox, we observed six related substances (impurities), namely deferasirox methyl ester, deferasirox salicylyl derivative, deferasirox ethyl ester, deferasirox methoxy carbonyl derivative, bis(salicyl)imide, and deferasirox-2-isomer. The present work describes the detection, origin, synthesis, and characterization of these related substances.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2011.580068