Insider access: pepducin symposium explores a new approach to GPCR modulation

The inaugural Pepducin Science Symposium convened in Cambridge, Massachusetts on March 8–9, 2009 provided the opportunity for an international group of distinguished scientists to present and discuss research regarding G protein–coupled receptor‐related research. G protein–coupled receptors (GPCRs)...

Full description

Saved in:
Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2009-11, Vol.1180 (s1), p.E1-E12
Main Authors: Miller, Jacquelyn, Agarwal, Anika, Devi, Lakshmi A., Fontanini, Kellen, Hamilton, James A., Pin, Jean-Philippe, Shields, Denis C., Spek, C. Arnold, Sakmar, Thomas P., Kuliopulos, Athan, Hunt III, Stephen W.
Format: Article
Language:English
Subjects:
Allosteric Regulation - drug effects
Allosteric Regulation - physiology
Animals
Computational Biology
Drug Delivery Systems - methods
Drug Evaluation
Female
G protein-coupled receptors
Humans
Ligands
Medical research
meeting report
Models, Biological
Models, Molecular
Morphine Dependence - etiology
Morphine Dependence - metabolism
Ovarian Neoplasms - drug therapy
pepducins
Pharmaceutical Preparations - isolation & purification
Proteins
Receptors, G-Protein-Coupled - agonists
Receptors, G-Protein-Coupled - antagonists & inhibitors
Receptors, G-Protein-Coupled - chemistry
Receptors, G-Protein-Coupled - metabolism
Sepsis - drug therapy
Synaptic Transmission - drug effects
transmembrane signaling
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The inaugural Pepducin Science Symposium convened in Cambridge, Massachusetts on March 8–9, 2009 provided the opportunity for an international group of distinguished scientists to present and discuss research regarding G protein–coupled receptor‐related research. G protein–coupled receptors (GPCRs) are, arguably, one of the most important molecular targets in drug discovery and pharmaceutical development today. This superfamily of membrane receptors is central to nearly every signaling pathway in the human body and has been the focus of intense research for decades. However, as scientists discover additional properties of GPCRs, it has become clear that much is yet to be understood about how these receptors function. Everyone agrees, however, that tremendous potential remains if specific GPCR signaling pathways can be modulated to correct pathological states. One exciting new approach to this challenge involves pepducins: novel, synthetic lipopeptide pharmacophores that modulate heptahelical GPCR activity from inside the cell membrane.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2009.05326.x