Oculogyric crisis in patients taking cetirizine

To report oculogyric crisis in patients receiving cetirizine and inform clinicians on the characteristics of this drug-induced ocular side effect. For this retrospective, observational case series, case reports were collected from the National Registry of Drug-Induced Ocular Side Effects (Casey Eye...

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Bibliographic Details
Published in:American journal of ophthalmology 2004-02, Vol.137 (2), p.355-357
Main Authors: Fraunfelder, Frederick W., Fraunfelder, Frederick T.
Format: Article
Language:English
Subjects:
Adverse Drug Reaction Reporting Systems - statistics & numerical data
Allergies
Anti-Allergic Agents - adverse effects
Biological and medical sciences
Cetirizine - adverse effects
Child
Child, Preschool
Drug dosages
Drug therapy
Drug toxicity and drugs side effects treatment
Dystonia - chemically induced
Female
Histamine H1 Antagonists, Non-Sedating - adverse effects
Humans
Infant
Male
Medical sciences
Middle Aged
Ocular Motility Disorders - chemically induced
Pharmacology. Drug treatments
Toxicity: eye
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Summary:To report oculogyric crisis in patients receiving cetirizine and inform clinicians on the characteristics of this drug-induced ocular side effect. For this retrospective, observational case series, case reports were collected from the National Registry of Drug-Induced Ocular Side Effects (Casey Eye Institute, Portland, Oregon). The World Health Organization Causality Assessment Guide of Suspected Adverse Reactions was used to categorize the cases. Nine cases were reported, with eight occurring in the pediatric age group. Dosage ranged from 5 to 10 mg orally and onset of symptoms ranged from 3 to 184 days. Six cases of oculogyric crisis had positive rechallenge data. Eight cases had complete neurologic consultation including radiographic studies. Cetirizine can cause oculogyric crisis, especially in the pediatric age group. Extensive neurologic workups may be avoided if clinicians recognize this drug-induced ocular side effect.
ISSN:0002-9394
1879-1891
DOI:10.1016/S0002-9394(03)00869-9