Pitfalls in Diagnosing the Simultaneous Presentation of Type 1 Diabetes and Thyrotoxicosis in a Pediatric Patient

The two conditions share several features of clinical presentation, including weight loss, irritability, tachycardia, and thirst. [...]it can be easy to miss this dual diagnosis.1 Pediatricians and other primary care providers seeing patients presenting with newly diagnosed type 1 diabetes should pe...

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Bibliographic Details
Published in:Clinical diabetes 2012-09, Vol.30 (4), p.168-169
Main Authors: Makaya, Tafadzwa, Wales, Jerry K.H, Price, Katherine J
Format: Article
Language:English
Subjects:
Autoimmune diseases
Cardiac arrhythmia
Case studies
Complications and side effects
Diabetes
Diagnosis
Disease
Drug therapy
Hypothyroidism
Risk factors
Thyroid diseases
Thyroid gland
Type 1 diabetes
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Summary:The two conditions share several features of clinical presentation, including weight loss, irritability, tachycardia, and thirst. [...]it can be easy to miss this dual diagnosis.1 Pediatricians and other primary care providers seeing patients presenting with newly diagnosed type 1 diabetes should perform a full clinical examination to look for signs of other autoimmune diseases. Approximately 1 out of every 700-1,000 children in the United Kingdom has type 1 diabetes.2 The pathophysiology of type 1 diabetes has an established autoimmune basis. [...]of diagnosis, children with type 1 diabetes should be screened for thyroid disorders and the related disorder of celiac disease.3 By far the most common thyroid autoimmune disorder in children with type 1 diabetes is hypothyroidism, which affects 2-5% of children with diabetes.4 Other case reports in the literature have described pediatric patients presenting simultaneously with type 1 diabetes and thyrotoxicosis.5·6 In their case reports, Abdullah et al.5 suggested that thyrotoxicosis resulted in an insulinresistant state and accelerated the presentation of the patient with hyperglycemia, whereas Duun et al.6 highlighted the fact that life stresses can precipitate either diabetes or thyrotoxicosis.
ISSN:0891-8929
1945-4953
DOI:10.2337/diaclin.30.4.168