Scleritis and other ocular side effects associated with pamidronate disodium

To evaluate reported cases of scleritis and other ocular side effects associated with pamidronate disodium, with emphasis on previously unreported cases of scleritis. Observational case series. Case reports from the National Registry of Drug-Induced Ocular Side Effects (Casey Eye Institute), the Foo...

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Bibliographic Details
Published in:American journal of ophthalmology 2003-02, Vol.135 (2), p.219-222
Main Authors: Fraunfelder, Frederick W, Fraunfelder, Frederick T, Jensvold, Bree
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Antineoplastic Agents - adverse effects
Biological and medical sciences
Conjunctivitis - chemically induced
Diphosphonates - adverse effects
Drug toxicity and drugs side effects treatment
Female
Humans
Male
Medical sciences
Middle Aged
Pain - chemically induced
Pamidronate
Pharmacology. Drug treatments
Scleritis - chemically induced
Toxicity: eye
Uveitis, Anterior - chemically induced
Vision Disorders - chemically induced
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Summary:To evaluate reported cases of scleritis and other ocular side effects associated with pamidronate disodium, with emphasis on previously unreported cases of scleritis. Observational case series. Case reports from the National Registry of Drug-Induced Ocular Side Effects (Casey Eye Institute), the Food and Drug Administration, the World Health Organization, and the literature were reviewed to determine possible adverse ocular side effects associated with pamidronate disodium. The World Health Organization’s Causality Assessment Guide was used to categorize an adverse drug reaction. Seventeen cases of unilateral scleritis and one case of bilateral scleritis occurred, usually within 6 hours to 2 days after intravenous pamidronate disodium. Six patients had positive rechallenge testing with the scleritis occurring after a repeat drug exposure. Other ocular side effects with positive rechallenge data, associated with pamidronate disodium, include blurred vision, nonspecific conjunctivitis, ocular pain, bilateral anterior uveitis, and episcleritis. This is the first report, with rechallenge data, of any drug causing scleritis. Pamidronate disodium can cause vision–threatening diseases, which may require discontinuing the drug in some uveitis cases and, in this series, all cases of scleritis.
ISSN:0002-9394
1879-1891
DOI:10.1016/S0002-9394(02)01840-8