Hybrid [alpha]/[beta]-peptides: For-Met-Leu-Phe-OMe analogues containing geminally disubstituted [beta]2,2- and [beta]3,3-amino acids at the central position

Hybrid [alpha]/[beta]-peptides: For-Met-Leu-Phe-OMe analogues containing geminally disubstituted [beta]2,2- and [beta]3,3-amino acids at the central position

Issue Title: Special issue: Proteins and Proteomics The two fMLF-OMe analogues For-Met-β^sup 3^hAc^sub 6^c-Phe-OMe (6) and For-Met-β^sup 2^hAc^sub 6^c-Phe-OMe (12) and their corresponding N-Boc derivatives 5 and 11 have been synthesized and their biological activity towards human neutrophils evaluat...

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Bibliographic Details
Published in:Amino acids 2006-06, Vol.30 (4), p.453
Main Authors: Mollica, A, Paglialunga Paradisi, M, Torino, D, Spisani, S, Lucente, G
Format: Article
Language:eng
Subjects:
Peptides
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Summary:Issue Title: Special issue: Proteins and Proteomics The two fMLF-OMe analogues For-Met-β^sup 3^hAc^sub 6^c-Phe-OMe (6) and For-Met-β^sup 2^hAc^sub 6^c-Phe-OMe (12) and their corresponding N-Boc derivatives 5 and 11 have been synthesized and their biological activity towards human neutrophils evaluated. The N-formyl peptides 6 and 12 exhibit good activity as chemoattractans and 12 is highly active in superoxide anion production. The preferred solution conformation of the two N-formyl derivatives has been discussed.[PUBLICATION ABSTRACT]
ISSN:0939-4451
1438-2199