Evaluation of the adverse effects of subcutaneous carprofen over six days in healthy cats

This study evaluated the adverse effects of carprofen in seven healthy cats. Values for CBC, biochemical profiles and platelet aggregation were measured before and at seven days after SID treatment with subcutaneous carprofen: 4 mg/kg (day 1), 2 mg/kg (day 2 and 3) and 1 mg/kg (day 4 and 6) (CG) or...

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Bibliographic Details
Published in:Research in veterinary science 2009-02, Vol.86 (1), p.115-120
Main Authors: Steagall, P.V.M., Moutinho, F.Q., Mantovani, F.B., Passarelli, D., Thomassian, A.
Format: Article
Language:English
Subjects:
Adverse effects
alanine phosphatase
Alkaline Phosphatase - blood
Analgesia
Animals
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - toxicity
Blood Cell Count - veterinary
blood cell counts
blood chemistry
Blood platelets
Bone surgery
Carbazoles - administration & dosage
Carbazoles - toxicity
Carprofen
Cat
Cats
Cats - blood
Creatinine - blood
Cross-Over Studies
dosage
Drug dosages
Drug therapy
endoscopy
Endoscopy - veterinary
Enzymes
Female
gamma-Glutamyltransferase - blood
gastrointestinal system
Gastrointestinal Tract - drug effects
globulins
Hematocrit - veterinary
Hemoglobins - analysis
Injections, Subcutaneous - veterinary
Male
nonsteroidal anti-inflammatory agents
NSAIDs
Pain
platelet aggregation
Platelet Aggregation - physiology
Platelet Count - veterinary
Random Allocation
Rodents
serum albumin
Studies
subcutaneous injection
temporal variation
Urea - blood
Veterinarians
Veterinary medicine
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Summary:This study evaluated the adverse effects of carprofen in seven healthy cats. Values for CBC, biochemical profiles and platelet aggregation were measured before and at seven days after SID treatment with subcutaneous carprofen: 4 mg/kg (day 1), 2 mg/kg (day 2 and 3) and 1 mg/kg (day 4 and 6) (CG) or 0.35 ml of saline (SG) for six days in a randomized, blinded, cross-over study with a four-week washout period. No treatment was given on day 5. Endoscopy of the GI tract was performed pre-treatment and on day 7 post-treatment. There were no significant changes in hematological profiles, biochemical profiles and endoscopy grading scores within nor between groups, except for lower albumin values at baseline than on day 7 (CG), and globulin and ALP values were higher at baseline than on day 7 in CG and SG. SC administration of carprofen over six days did not cause any adverse effects on gastrointestinal, hematological, or serum biochemical variables.
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2008.04.002