Cytogenetic evidence of metastatic myxoid liposarcoma and therapy-related myelodysplastic syndrome in a bone marrow biopsy

Summary Myxoid liposarcoma exhibits a peculiar clinical behavior, with a tendency to spread to serosal membranes, distant soft tissues, and bones, even in the absence of lung metastases. Therapy-related hematological neoplasms are well-known side effects of cytotoxic chemotherapy. We describe an exc...

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Bibliographic Details
Published in:	Human pathology 2009-07, Vol.40 (7), p.1040-1044
Main Authors:	Rossi, Sabrina, MD, Canal, Fabio, MD, Licci, Stefano, MD, Zanatta, Lucia, BSc, Laurino, Licia, MD, Gottardi, Michele, MD, Gherlinzoni, Filippo, MD, Dei Tos, Angelo Paolo, MD
Format:	Article
Language:	eng
Subjects:	Adult Anemia, Refractory - pathology Antineoplastic Combined Chemotherapy Protocols - adverse effects Biological and medical sciences Bone Marrow Cells - pathology Bone metastasis Chromosomes, Human, Pair 11 Combined Modality Therapy - adverse effects cytogenetics Diseases of the osteoarticular system Female FISH Humans Investigative techniques, diagnostic techniques (general aspects) Leukemia, Myeloid, Acute - pathology Liposarcoma, Myxoid - pathology Liposarcoma, Myxoid - secondary Medical sciences Myelodysplastic Syndromes - pathology Myxoid liposarcoma Neoplasms, Second Primary - pathology Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques RAEB Soft Tissue Neoplasms - pathology Therapy-related myelodysplastic syndrome Thigh - pathology Tumors of striated muscle and skeleton
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Summary:	Summary Myxoid liposarcoma exhibits a peculiar clinical behavior, with a tendency to spread to serosal membranes, distant soft tissues, and bones, even in the absence of lung metastases. Therapy-related hematological neoplasms are well-known side effects of cytotoxic chemotherapy. We describe an exceptional case of metastatic myxoid liposarcoma of the spine associated with therapy-related refractory anemia with excess of blasts in a 37-year-old woman who underwent multi-agent chemotherapy for a myxoid liposarcoma of the left thigh. Microscopic examination of the bone marrow biopsy revealed dysplastic features, with abnormal localization of immature precursors and micromegakaryocytes, and islands of undifferentiated oval small/medium-size cells, suggestive of acute myeloid leukemia arising in the setting of a myelodysplastic syndrome. Immunohistochemistry was not discriminant. Cytogenetic analyses of bone marrow aspirate disclosed the presence of 2 different rearrangements, subsequently confirmed by fluorescent in situ hybridization and was crucial in making the correct diagnosis.
ISSN:	0046-8177 1532-8392