A systematic review of cardiovascular effects after atypical antipsychotic medication overdose

Abstract As the use of atypical antipsychotic medications (AAPMs) increases, the number of overdoses continues to grow. Cardiovascular toxicity was common with older psychiatric medications but seems uncommon with AAPM. We conducted a systematic literature review to describe the cardiovascular effec...

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Bibliographic Details
Published in:The American journal of emergency medicine 2009-06, Vol.27 (5), p.607-616
Main Authors: Tan, Hock Heng, MBBS, Hoppe, Jason, DO, Heard, Kennon, MD
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Antipsychotic Agents - poisoning
Aripiprazole
Benzodiazepines - poisoning
Biological and medical sciences
Cardiac arrhythmia
Cardiovascular System - drug effects
Dibenzothiazepines - poisoning
Drug dosages
Drug intoxications. Doping
Drug Overdose
Drug therapy
Emergency
Emergency medical care
Humans
Intensive care medicine
Medical sciences
Olanzapine
Pharmacology. Drug treatments
Piperazines - poisoning
Poisoning
Poisons
Psychotropic drugs
Quetiapine Fumarate
Quinolones - poisoning
Risperidone - poisoning
Thiazoles - poisoning
Variables
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Description
Summary:Abstract As the use of atypical antipsychotic medications (AAPMs) increases, the number of overdoses continues to grow. Cardiovascular toxicity was common with older psychiatric medications but seems uncommon with AAPM. We conducted a systematic literature review to describe the cardiovascular effects reported after overdose of 5 common AAPM: aripiprazole, olanzapine, quetiapine, risperidone, and ziprasidone. We included case reports and case series describing overdose of these 5 medications identified in a search of MEDLINE, EMBASE, and abstracts from major toxicology meetings. We found 13 pediatric cases (age,
ISSN:0735-6757
1532-8171
DOI:10.1016/j.ajem.2008.04.020