P-236: Effects of long term treatment with ACEI and angiotensin II antagonists (AIIA) on time domain measures of HRV in essential hypertensive patients

Aim Several studies demonstrated that essential hypertension (EH) is associated to sympathetic activation. Consequently, one of the major aims of antihypertensive therapy should be to attenuate the sympathetic tone. Time Domain (TD) analysis of HRV is a simple and practical method for the assessment...

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Bibliographic Details
Published in:American journal of hypertension 2001-04, Vol.14 (S1), p.107A-107A
Main Authors: Cat Genova, Gianluca, Rabbia, Franco, Conterno, Andrea, Milan, Alberto, Martini, Gianpiero, Carra, Renata, Grosso, Tiziana, Chiandussi, Livio, Veglio, Franco
Format: Article
Language:English
Subjects:
antihypertensive drugs
Heart rate variability
sympathetic nervous system
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Summary:Aim Several studies demonstrated that essential hypertension (EH) is associated to sympathetic activation. Consequently, one of the major aims of antihypertensive therapy should be to attenuate the sympathetic tone. Time Domain (TD) analysis of HRV is a simple and practical method for the assessment of autonomic function.: to assess the effects of an ACEI (fosinopril) and an AIIA (irbesartan) on cardiac autonomic tone by usingTD) analysis of HRV. Methods: 45 mild-moderate untreated EH patients were randomly assigned to fosinopril (F) 20 mg, or irbesartan (I) 150 mg, or atenolol(A) 100 mg o.d treatment. The βblocker A was included as a control drug because its marked effects on HRV. Combined 24-h ecg Holter and ABPM recordings were performed after 2 weeks placebo and after 12 weeks treatment. The TD parameters measured (calculated as 24-h, daytime and nighttime) were the following: PNN50 and RMSSD, short term parameters and indexes of parasympathetic activity. SD and SDANN: long term parameters and related to diurnal and secular trends in HRV. Results: the three groups of patients were comparable for clinical features. All three drugs significantly and similarly decreased office and ABP values vs placebo. Mean RR was significantly increased after A. and unmodified after F and I. 24-h and daytime PNN50 and RMSSD were significantly increased by A (+ 69% PNN50, and +39%RMSSD p
ISSN:0895-7061
1879-1905
1941-7225
DOI:10.1016/S0895-7061(01)01426-1